ID G1PIB7_MYOLU Unreviewed; 1490 AA.
AC G1PIB7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Roundabout guidance receptor 1 {ECO:0000313|Ensembl:ENSMLUP00000010442.2};
GN Name=ROBO1 {ECO:0000313|Ensembl:ENSMLUP00000010442.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010442.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010442.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010442.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02026990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02026991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02026992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02026993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000010442; -.
DR Ensembl; ENSMLUT00000011461.2; ENSMLUP00000010442.2; ENSMLUG00000011434.2.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000154477; -.
DR HOGENOM; CLU_003227_3_0_1; -.
DR InParanoid; G1PIB7; -.
DR OMA; XDILPYC; -.
DR TreeFam; TF351053; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030275; F:LRR domain binding; IEA:Ensembl.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0021836; P:chemorepulsion involved in postnatal olfactory bulb interneuron migration; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0070100; P:negative regulation of chemokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0050925; P:negative regulation of negative chemotaxis; IEA:Ensembl.
DR GO; GO:0050772; P:positive regulation of axonogenesis; IEA:Ensembl.
DR GO; GO:0035025; P:positive regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:1900748; P:positive regulation of vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR CDD; cd05724; IgI_2_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF32; MYOTILIN; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 4..96
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 101..185
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 190..285
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 294..380
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 402..496
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 515..612
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 617..713
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 922..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1067..1176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1191..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..1005
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1147
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1196..1236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1277..1294
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1355..1378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1393..1416
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1429..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1490 AA; 162901 MW; 590A3B246C0CFAA4 CRC64;
TLVPAVLRDD FRQNPSDVMV AVGEPAVMEC QPPRGHPEPT ISWKKDGSSL DDKDERITIR
GGKLMITYTR KSDAGKYVCV GTNMVGERES EVAELTVLER PSFVKRPSNL AITVDDSAEF
KCEARGDPVP TVRWRKDDGE LPKSRYEIRD DHTLKIRKVM AGDMGSYTCV AENMVGKAEA
SATLTVQEPP HFVVKPRDQV VALGRTVTFQ CEATGNPQPA IFWRREGSQN LLFSYQPPQS
SSRFSVSQTG DLTITNVQRS DVGYYICQTL NVAGSIITKA YLEVTDVIAD RPPPVIRQGP
VNQTVAVDGT LVLSCVATGS PVPTILWRKD GVLVSTQDSR IKQLETGVLQ IRYAKLGDTG
RYTCIATTPS GEATWSAYIE VQEFGVPVQP PRPTDPNLIP SAPSKPEVID VSRNTVTLSW
QPNLNSGATP TSYILEAFSH ASGSSWQTVA ENVKTETFAI KGLKPNAIYL FLVRAANAYG
ISDPSQISDP VKTQDVPPTS QGVDHKQVQR ELGDVVLHLH NPTILSSSSI EVHWTVDQQS
QYIQGYKILY RPSGATHGES EWLVFEVRTP TKNSVVIPDL KKGVNYEIKA RPFFNEFQGA
DSEIKFAKTL EEAPSAPPQS VTVSKNDGNG TAILVSWQPP PEDTQNGMVQ EYKVWCLGNE
TRYHINKTVD GSTFSVVIPS LVPGIRYSVE VAASTGAGPG VKSEPQFIQL DSHGNPVSPE
DQVSLAQQIS DVVKQPAFIA GLGAACWVIL MVFSIWLYRH RKKRNGLTST YAGIRKVPSF
TFTPTVTYQR GGEAVSSGGR PGLLNISEPA AQPWLADTWP NTGNNHNDCS INCCTAGSGN
SDSNLTTYSR PADCIANYNN QLDNKQTNLM LPESTVYGDV DLSNKINEMK TFNSPNLKDG
RFVNPSGQPT PYATTQLIQS NLSNNMNNGS GDSGEKHWKP PGQQKQEMAP IQYNIMEQNK
LNKDYRANDT IPPTIPYNQS YDQNTGGSYN SSDRGSSTSG SQGHKKGART PKVPKQGGMN
WADLLPPPPA HPPPHSNSEE FSISVDESYD QEMPCPVPPA RMYLQQNELE EEEDERGPTP
PIRGAASSPA AVSYSHQSTA TLTPSPQEEL QPMLQDCPEE TGHMQHQPDR RRQPVSPPPP
PRPISPPHTY GYISGPLVSD MDTDAPEEEE DEADMEVAKM QTRRLLLRGL EQTPASSVGD
LESSVTGSMI NGWGSASEED NISSGRSSVS SSDGSFFTDA DFAQAVAAAA EYAGLKVARR
QMQDAAGRRH FHASQCPRPT SPVSTDSNMS TAVMQKARPA KKPKHQPGHL RREAYTDDLP
PPPVPPPAIK SPTVQSKAQL EVRPVMVPKL PCIEARTDRS SDRKGGNYKG REVLDGRQVA
EMRTNPGEPR EAQEQQNDGK GRGNKAAKRD LPPAKTHLIQ EDILPYCRPT FPTSNNPRDP
SSSSSMSSRG SGSRQREQAN VGRRNIAEMQ VLGGYERGGD NNEELEETES
//
