ID G1PJ28_MYOLU Unreviewed; 508 AA.
AC G1PJ28;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Cytochrome P450 family 4 subfamily X member 1 {ECO:0000313|Ensembl:ENSMLUP00000010741.2};
GN Name=CYP4X1 {ECO:0000313|Ensembl:ENSMLUP00000010741.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000010741.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000010741.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000010741.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC Evidence={ECO:0000256|ARBA:ARBA00001971};
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR EMBL; AAPE02014858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02014859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02014860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006087341.1; XM_006087279.2.
DR AlphaFoldDB; G1PJ28; -.
DR STRING; 59463.ENSMLUP00000010741; -.
DR Ensembl; ENSMLUT00000011789.2; ENSMLUP00000010741.2; ENSMLUG00000011781.2.
DR GeneID; 102417369; -.
DR KEGG; mlf:102417369; -.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000160927; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR InParanoid; G1PJ28; -.
DR OMA; VLHQYTE; -.
DR OrthoDB; 1611592at2759; -.
DR TreeFam; TF105088; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0062189; F:anandamide 14,15 epoxidase activity; IEA:Ensembl.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291:SF63; CYTOCHROME P450 4X1-RELATED; 1.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 508 AA; 58840 MW; 7AE59D4AB42EA4C8 CRC64;
METSWLEMRW ARPFYLVFVS FLTLVLLQAI KLFLRRQQLL RDLRPFPGPS PLHWLTGHQK
LFRDGDFESI EEFVKKYPCG FPAWIGPFEV FFQIYDPDYA KTFLSRTDPK SQYLYRFLAS
LLGEGLLSLH GIRWSQHRRL ITPAFNFNIL KSHTSVMAQS VNVMLDKWEK VCGAQESVLE
VFEDISLMSL DTLMKCTFSR ETNCQINSSH DHYAKGLCES SEIVYNRLFR FLYHSDIIFK
FSPEKRRLQK IIKTLHQYTD QIIRERRKAL KDEKEHGKTG NRKFRDFLDI LLSAQDEHGN
SFSDADLYAE VNTFMVAGQD TVGGSLAWLL HLLAQNPEHQ ERCREEIMDI LGDGSSITWD
HLGEMTYTTM CIKESLRLCP TVFSLARQLS QPITFPDGRS LPAGVTVSLN IWGLHHNPAV
WENPQVFDPL RFSPDNYDKR HSHSFLPFSG GPRNCIGQHF AMTELKVAIA MILLRFKITP
DPTRPLTIVP KILLKPKNGL YLSLKKIS
//
