ID G1PKV7_MYOLU Unreviewed; 305 AA.
AC G1PKV7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=HORMA domain containing 2 {ECO:0000313|Ensembl:ENSMLUP00000011460.2};
GN Name=HORMAD2 {ECO:0000313|Ensembl:ENSMLUP00000011460.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000011460.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000011460.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000011460.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AAPE02038418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PKV7; -.
DR STRING; 59463.ENSMLUP00000011460; -.
DR Ensembl; ENSMLUT00000012594.2; ENSMLUP00000011460.2; ENSMLUG00000012592.2.
DR eggNOG; KOG4652; Eukaryota.
DR GeneTree; ENSGT00390000018130; -.
DR HOGENOM; CLU_058638_2_0_1; -.
DR InParanoid; G1PKV7; -.
DR OMA; YLQIVFI; -.
DR TreeFam; TF313989; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000795; C:synaptonemal complex; IEA:Ensembl.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051177; P:meiotic sister chromatid cohesion; IEA:Ensembl.
DR Gene3D; 3.30.900.10; HORMA domain; 1.
DR InterPro; IPR003511; HORMA_dom.
DR InterPro; IPR036570; HORMA_dom_sf.
DR PANTHER; PTHR48225; HORMA DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR48225:SF6; HORMA DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF02301; HORMA; 1.
DR SUPFAM; SSF56019; The spindle assembly checkpoint protein mad2; 1.
DR PROSITE; PS50815; HORMA; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 29..232
FT /note="HORMA"
FT /evidence="ECO:0000259|PROSITE:PS50815"
FT REGION 260..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 305 AA; 34215 MW; B12E609F75F1E5ED CRC64;
MAIAQLSHSI RINKASKGPI FPSQICDQEE SLTMVKKLFA TSVSCITYLR GLFPESSYGN
RYVEDLNLKI LREDENSPGS VHIIKWIRGC FDALERGYLH MAILTLYPNP KEPEKVTEIY
QFKFKYTNEG ITMDFDSSNT STESGTKRGH MKKASILLLR KLYILMQNLG PLPNDVVLTM
KLHYYSAVTP DYYQPPGFKH GVNSHVLLFE GEPVNLQVGV ASTGFHSMKL KVITEATRVS
DLEDNLFQEN SVTEIAHQGL DGDEEEEGSN NQVRQSFREP PCFSETADTG IKVGSFVTVF
IPGTS
//
