ID G1PMR6_MYOLU Unreviewed; 870 AA.
AC G1PMR6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=WD repeat-containing protein 44 {ECO:0000256|ARBA:ARBA00021207};
GN Name=WDR44 {ECO:0000313|Ensembl:ENSMLUP00000012202.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012202.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012202.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012202.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAPE02002543; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02002544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PMR6; -.
DR STRING; 59463.ENSMLUP00000012202; -.
DR Ensembl; ENSMLUT00000013413.2; ENSMLUP00000012202.2; ENSMLUG00000013400.2.
DR eggNOG; KOG0283; Eukaryota.
DR GeneTree; ENSGT00940000157557; -.
DR HOGENOM; CLU_009835_2_1_1; -.
DR InParanoid; G1PMR6; -.
DR OMA; SQECVRP; -.
DR TreeFam; TF329226; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0140313; F:molecular sequestering activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0061824; P:cytosolic ciliogenesis; IEA:Ensembl.
DR GO; GO:1902018; P:negative regulation of cilium assembly; IEA:Ensembl.
DR GO; GO:0060627; P:regulation of vesicle-mediated transport; IEA:Ensembl.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040324; WDR44/Dgr2.
DR PANTHER; PTHR14221; WD REPEAT DOMAIN 44; 1.
DR PANTHER; PTHR14221:SF0; WD REPEAT-CONTAINING PROTEIN 44; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 468..503
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 564..597
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 604..638
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 754..775
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 42..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 358..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..165
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 193..217
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..542
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 96785 MW; 62A46C82C43F08BE CRC64;
ETENTAHKVG NESPVQELKQ DVRNKIIESI IEETQKVLQL DDDSLDSKGK GQSDQATASP
LVAGTDLNNI PGLLATGQVL QEYPKRAESQ NTCEETELEP KKCFSSNDTC EKPVDETTKL
TEISSTKQLN VTETETEVLN KEAVEIKGSD VLESASSSSS SAKDFATVEE LAPAKPPRQL
TPEPDIVAST KKPVPARPPP PTNFPPPRPP PPSRPAPPPR KKKSELEFEA LKTPDLDVPK
DNITSDTLTT SMASESTVKD SQPSLDLASA TSGDKIVTAQ ENGKAPDGQT IAGEVMSPQR
PRSNSGRELT DEEILASVMI KNLDTGEEIP LSLAEEKLPT GINPLTLHIM RRTKEYVSND
AAQSDDEDKL QSHPTDTDGG RLKQKTTQLK KFLGKSVKRA KHLAEEYGER AVNKVKSVRD
EVFHTDQDDP SSSDDEGMPY TRPVKFKAAH GFKGPYDFDQ IKVVQDLSGE HMGAVWTMKF
SHCGRLLASA GQDNVVRIWA LKNAFDYFNN MRMKYNTEGR VSPSPSQESL NSSKSDTDTG
VCSGTDEDTD DKNAPFRQRP FCKYKGHTAD LLDLSWSKNY FLLSSSMDKT VRLWHISRRE
CLCCFQHIDF VTAIAFHPRD DRYFLSGSLD GKLRLWNIPD KKVALWNEVD GQTKLITAAN
FCQNGKYAVI GTYDGRCIFY DTEHLKYHTQ IHVRSTRGRN KVGRKITGIE PLPGENKILV
TSNDSRIRLY DLRDLSLSMK YKGYVNSSSQ IKASFSHDFS YLVSGSEDKY VYIWSTYHDL
SKFTSVRRDR NDFWEGIKAH NAVVTSAIFA PNPSLMLSLD VQSEKSESED AEVLDTIPSG
IMKTDNTEVL LSADFTGAIK VFINKRKNVS
//
