ID G1PNI1_MYOLU Unreviewed; 2528 AA.
AC G1PNI1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Teneurin transmembrane protein 2 {ECO:0000313|Ensembl:ENSMLUP00000012506.2};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSMLUP00000012506.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012506.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012506.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012506.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAPE02031900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031903; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02031905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 59463.ENSMLUP00000012506; -.
DR Ensembl; ENSMLUT00000013744.2; ENSMLUP00000012506.2; ENSMLUG00000013724.2.
DR eggNOG; KOG1225; Eukaryota.
DR eggNOG; KOG4659; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR HOGENOM; CLU_000229_0_0_1; -.
DR InParanoid; G1PNI1; -.
DR OMA; MCEPSPH; -.
DR TreeFam; TF316833; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SMART; SM00179; EGF_CA; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 137..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..137
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 398..430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 464..497
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 568..603
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 420..429
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 487..496
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 572..582
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 593..602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2528 AA; 280030 MW; 0E5B31AC85EE79C5 CRC64;
GPPNHSQSTL RPPLPPPHNH TLSHHHSSAN SLNRNSLTNR RSQIHAPAPA PNDLATTPES
VQLQDSWVLN SNVPLETRHF LFKTSSGSTP LFSSSSPGYP LTSGTVYTPP PRLLPRNTFS
RKAFKLKKPS KYCSWKCAAL SAIAAALLLA ILLAYFIAMH LLGLNWQLQP ADGHTFNNGI
RTGLPGNDDV ATMPSGGKGP WSLKNSSIDS GEAEVGRRVT QEVPPGVFWR SQIHISQPQF
LKFNISLGKD ALFGVYIRRG LPPSHAQYDF MERLDGKEKW SVVESPRERR SIQTLVQNEA
VFVQYLDVGL WHLAFYNDGK DKEMVSFNTV VLDSVQDCPR NCHGNGECVS GLCHCFPGFL
GADCAKAACP VLCSGNGQYS KGTCQCYSGW KGAECDVPMN QCIDPSCGGH GSCIDGTCVC
SAGYKGEHCE EVDCLDPTCS SHGVCVNGEC LCSPGWGGLN CELARVQCPD QCSGHGTYLP
DTGLCSCDPN WMGPDCSVEV CSVDCGTHGV CIGGACRCEE GWTGAACDQR VCHPRCIEHG
TCKDGKCECR EGWNGEHCTI GRQTAGTETD GCPDLCNGNG RCTLGQNSWQ CVCQTGWRGP
GCNVAMETSC ADNKDNEGDG LVDCLDPDCC LQSACQNSLL CRGSRDPLDI IQQGQTDSPA
VKSFYDRIKL LAGKDSTHII PGDNPFNSSL VSLIRGQVVT TDGTPLVGVN VSFVKYPKYG
YTITRQDGTF DLIANGGASL TLHFERAPFM SQNSFYAMDT LVMKTEENSI PSCDLSGFVR
PDPIIISSPL STFFSAAPGH NPIVPETQVL HEEIELPGSN VKLRYLSSRT AGYKSLLKIT
MTQSTVPLNL IKVHLMVAVE GHLFQKSFQA SSNLAYTFIW DKTDAYGQSV YGLSDAVVSV
GFEYETCPSL ILWEKRTALL QGFELDPSNL GGWSLDKHHI LNVKSGILHK GTGENQFLTQ
QPAIITSIMG NGRRRSISCP SCNGLAEGNK LLAPVALAVG VDGSLFVGDF NYIRRIYPSR
NVTSILELRN KEFKHSNNPA HKYYLAVDPV SGSLYVSDTN SRRIYRVKSL SGAKDLAGNS
EVVAGTGEQC LPFDEARCGD GGKAVDATLM SPRGIAVDKN GLMYFVDATM IRKVDQNGII
STLLGSNDLT AVRPLSCDSS MDVAQVRLEW PTDLAVNPMD NSLYVLENNV ILRITENHQV
SIIAGRPMHC QVPGIDYSLS KLAIHSALES ASAIAISHTG VLYITETDEK KINRLRQVTT
NGEICLLAGA ASDCDCKNDV NCNCYSGDDA YATDAILNAP SSLAVAPDGT IYIADLGNIR
IRAVSKNKPV LNAFNQYEAA SPGEQELYVF NADGIHQYTV SLVTGEHLYN FTYSADNDVT
ELIDNSGNSL KIRRDSSGVA RHLLMPDNQI ITLTVGTNGG LKVVATQTLE LGLMTYDGNT
GLLATKSDET GWTTFYDYDH EGRLTNVTRP TGVVTSLHRE MEKSITIDIE NSNRDDDVTV
ITNLSSVEAS YTVVQDQVRN SYQLCNNGTL RVMYANGMGV SFHSEPHVLA GTITPTIGRC
NISLPMENGL NSIEWRLRKE QIKGKVTIFG RKLRVHGRNL LSIDYDRNIR TEKIYDDHRK
FTLRIIYDQV GRPFLWLPSS GLAAVNVSYF FNGRLAGLQR GAMSERTDID KQGRIVSRMF
ADGKVWSYSY LDKSMVLLLQ SQRQYIFEYD SSDRLHAVTM PSVARHSMST HTSIGYIRNI
YNPPESNASV IFDYSDDGRI LKTSFLGTGR QVFYKYGKLS KLSEIVYDST AVTFGYDETT
GVLKMVNLQS GGFSCTIRYR KIGPLVDKQI YRFSEEGMVN ARFDYTYHDN SFRIASIKPV
ISETPLPVDL YRYDEISGKV EHFGKFGVIY YDINQIITTA VMTLSKHFDT HGRIKEVQYE
MFRSLMYWMT VQYDSMGRVI KRELKLGPYA NTTKYTYDYD GDGQLQSVAV NDRPTWRYSY
DLNGNLHLLN PGNSVRLMPL RYDLRDRITR LGDVQYKIDD DGYLCQRGAD IFEYNSKGLL
TRAYNKASGW SVQYRYDGVG RRASYKTNLG HHLQYFYSDL HNPTRITHVY NHSNSEITSL
YYDLQGHLFA MESSSGEEYY VASDNTGTPL AVFSINGLMI KQLQYTAYGE IYYDSNPDFQ
MVIGFHGGLY DPLTKLVHFT QRDYDVLAGR WTSPDYTMWK NVGKEPAPFN LYMFKSNNPL
SNELDLKNYV TDVKSWLVMF GFQLSNIIPG FPRAKMYFVP PPYELSESQA SENGQLITGV
QQTTERHNQA FLALEGQVIS KKLHASIREK AGHWFATTTP IIGKGILFAI KEGRVSTGVS
SIASEDSRKV ASVLNNAYYL DKMHYSIEGK DTHYFVKIGA ADGDLVTLGT TIGRKVLESG
VNVTVSQPTL LVNGRTRRFT NVEFQYNTLL LSIRYGLTPD TLDEEKARVL DQARQRALGT
AWAKEQQRAR DGREGSRLWT EGERQQLLSA GRVQGYEGYY VLPVEQYPEL ADCSSNIQFL
RQNEMGKR
//
