ID G1PNN5_MYOLU Unreviewed; 926 AA.
AC G1PNN5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Glutamate receptor {ECO:0000256|RuleBase:RU367118};
GN Name=GRID2 {ECO:0000313|Ensembl:ENSMLUP00000012568.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000012568.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000012568.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000012568.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for glutamate that functions as a ligand-gated ion
CC channel in the central nervous system and plays an important role in
CC excitatory synaptic transmission. L-glutamate acts as an excitatory
CC neurotransmitter at many synapses in the central nervous system.
CC {ECO:0000256|RuleBase:RU367118}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367118};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367118}.
CC Postsynaptic cell membrane {ECO:0000256|RuleBase:RU367118}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|RuleBase:RU367118}.
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DR EMBL; AAPE02007825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02007834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1PNN5; -.
DR STRING; 59463.ENSMLUP00000012568; -.
DR Ensembl; ENSMLUT00000013813.2; ENSMLUP00000012568.2; ENSMLUG00000013810.2.
DR eggNOG; KOG1052; Eukaryota.
DR GeneTree; ENSGT00940000155192; -.
DR HOGENOM; CLU_007257_9_0_1; -.
DR InParanoid; G1PNN5; -.
DR OMA; EXISNLY; -.
DR TreeFam; TF352434; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:1904861; P:excitatory synapse assembly; IEA:Ensembl.
DR GO; GO:1900454; P:positive regulation of long-term synaptic depression; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR CDD; cd13731; PBP2_iGluR_delta_2; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF109; GLUTAMATE RECEPTOR IONOTROPIC, DELTA-2; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367118};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU367118};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU367118};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU367118};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367118};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257,
KW ECO:0000256|RuleBase:RU367118};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367118};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU367118};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367118};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367118};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367118}.
FT TRANSMEM 486..506
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 555..577
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT TRANSMEM 750..774
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367118"
FT DOMAIN 361..726
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 371..433
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 926 AA; 104086 MW; F097CB566F72D46A CRC64;
ACELMNQGIL ALVSSIGCTS AGSLQSLADA MHIPHLFIQR ATAGTPRSGC GLTRSNRNDD
YTLSVRPPVY LNEVILKVIT EYAWQKFIIF YDSEYDIRGI QEFLDRVSQQ GMDVALQKVE
NNINKMITTL FDTMRIEELN RYRDTLRRAI LIMNPATAKS FITEVVETNL VAFDCHWIII
NEEINDMDVQ ELVRRSIGRL TIIRQTFPVP QNISQRCFRG NHRISSTLCD PKDPFAQNME
ISNLYIYDTV LLLANAFHKK LEDRKWHSMA SLSCIRKNSK PWQGGRSMLE TIKKGGVSGL
TGELEFGENG GNPNVHFEIL GTNYGEELGR GIRKLGCWNP VTGLNGSLTD KKLENNMRGV
VLRVVTVLEE PFVMVSENVL GKPKKYQGFS IDVLDALSNY LGFNYDIYVA PDHKYGSPQE
DGTWNGLVGE LVFKRADIGI SALTITPDRE NVVDFTTRYM DYSVGVLLRR AEKTVDMFAC
LAPFDLSLWA CIAGTVLLVG LLVYLLNWLN PPRLQMGSMS STTLYNSMWF VYGSFVQQGG
EVPYTTLATR MMMGAWWLFA LIVISSYTAN LAAFLTITRI ESSIQSLQDL SKQTDIPYGT
VLDSAVYEHV RMKGMNPFER DSMYSQMWRM INRSNGSENN VLESQAGIQK VKYGNYAFVW
DAAVLEYVAI NDPDCSFYTI GNTVADRGYG IALQHGSPYR DVFSQRILEL QQNGDMDILK
HKWWPKNGQC DLYSSVDTKQ KGGALDIKSF AGVFCILAAG IVLSCLIAML ETWWNKRKGS
RVPSKEDDKE IDLEHLHRRV NSLCTDDDSP HKQFSTSSID LTPLDIDTLP TRQALEQISD
FRNTHITTTT FIPEQIQTLS RTLSAKAASG FAFGNVPEHR TGPFRHRAPN GGFFRSPIKT
MSSIPYQPTP TLGLNLGSDP DRGTSI
//
