ID G1PRN7_MYOLU Unreviewed; 437 AA.
AC G1PRN7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
GN Name=LOC102442579 {ECO:0000313|Ensembl:ENSMLUP00000013813.2};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000013813.2, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000013813.2, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000013813.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAPE02029685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_006095034.1; XM_006094972.1.
DR AlphaFoldDB; G1PRN7; -.
DR STRING; 59463.ENSMLUP00000013813; -.
DR Ensembl; ENSMLUT00000015163.2; ENSMLUP00000013813.2; ENSMLUG00000015158.2.
DR GeneID; 102442579; -.
DR KEGG; mlf:102442579; -.
DR eggNOG; ENOG502SIYJ; Eukaryota.
DR GeneTree; ENSGT00940000162088; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; G1PRN7; -.
DR OMA; QSYFCTI; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF110; KERATIN, TYPE I CUTICULAR HA8; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 83..394
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 87..157
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 338..379
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 437 AA; 49138 MW; 2C5B28C312FB7A2E CRC64;
MTSDHCSSPL RGQVSEAKAA CQGLLASLAH ANRVRVGTTP LGRPNLCLPN SCHNACPLPG
TRNIPANIGS CGAYGEGTLN GHEKETMQFL NDRLANYLQK VRQLEQENAE LETKIREWSK
CHETTMCPNY QCYFQTIEEL QQKILCIKSE NNRLVIQVDN AKLAADDFRT KYQMEHSLYQ
LVEADICGLR RALDDLTLAK CDLEAQVESL KEELLCLKKN HEQEVHTLTC QLGDRLLIEL
DTEPTVDLSR VLEEMRCQYE TMVETNRRDV EQWFQAQSEG ISLQATSCSE ELQCCQSEIL
ELRRTVNALE VELQAQHHLK DCLQNSLCEA EARFGTELAQ MQCLISTVEE QLAEIRADLE
RQNQEYQVLL DVKARLEGEI ATYRNLLESE DFKLPCNPCT TPASSTPCPA PAACTPCPPC
PSRPLQASYG PCSSPQR
//
