ID G1QBX3_MYOLU Unreviewed; 1137 AA.
AC G1QBX3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=NLR family pyrin domain containing 1 {ECO:0008006|Google:ProtNLM};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021206.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021206.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021206.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Inflammasome
CC {ECO:0000256|ARBA:ARBA00004110}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; AAPE02041242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAPE02041243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QBX3; -.
DR STRING; 59463.ENSMLUP00000021206; -.
DR Ensembl; ENSMLUT00000023603.1; ENSMLUP00000021206.1; ENSMLUG00000030557.1.
DR eggNOG; ENOG502S4A4; Eukaryota.
DR GeneTree; ENSGT00940000162176; -.
DR HOGENOM; CLU_002274_2_4_1; -.
DR InParanoid; G1QBX3; -.
DR OMA; SWMVCTC; -.
DR TreeFam; TF340267; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0061702; C:canonical inflammasome complex; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0012501; P:programmed cell death; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08330; CARD_ASC_NALP1; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR033516; CARD8/ASC/NALP1_CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR025307; FIIND_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46985; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46985:SF3; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13553; FIIND; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00368; LRR_RI; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS51830; FIIND; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022670};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammasome {ECO:0000256|ARBA:ARBA00023233};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Necrosis {ECO:0000256|ARBA:ARBA00022590};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 114..423
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT DOMAIN 763..1045
FT /note="FIIND"
FT /evidence="ECO:0000259|PROSITE:PS51830"
FT DOMAIN 1055..1137
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1137 AA; 130315 MW; E2E53FB01B406397 CRC64;
RSLDHDSRGS QVGHLYHHKH SPKEKGQSHS NILKGRIKEK YQNQRRESSC PTQSWKNEYL
HQKFTQLLFL HRSQPRGYDF LLRRRNHEVV DEQENWMEIG DLIGPGLSTQ EEPPTVVVHG
VAGIGKSTLA RQVRRAWEEG WLFRDLFKHV FYFNCRELAQ SETMSLAELI TKDWAAPDAP
IGQILSQPEQ LLFILDNLDE PKWDLKEQSS ELCPHWSQQQ QVHTLLGSLL KKTLLPTASL
LITARITALR KLIPSLKHPH WVEVLGFSES ARKEYFFQYF TDESQAIRAF TLVESNPALF
TMCLMPLVSW LVCTCLKQQM EQEQPLSLTS QTTTALCLHY FFHVLQAQSL GTKLRGFCSL
AVEGTCQGKT LFSPKDFREH GLDGANISTL LNMGVLKEHP TPQSYSFIHL CFQEFFAAMS
YALGDGVLKG DCFNNIIITI DLTGVYDRHD LFGEPTTCFL FGLLSDQGMR EMETIFKCSL
SRKRLPSLLH LAKREVLLKR LNLDPYSWHL LHCFYEIQDE DFMKNIFIPF TLRICVQTDM
ELLLFTFFFT FCHRIERLQL NEGGQHRQAG RTSGAFLYSW GPFTDSWWQM FFSILKVPRS
LRELDLSGNS LSCSAVQSLC DALKSPHCRL ATLRLVRCGL TYNCCQDLAS MLGASPNLTE
LDLRQNDLGD LGVRLLCEGL RQPACQLRNL WLNLTRLSEE VRQAERALER IDHSHSISTH
INNHARCPGM EGGQGPETEL SSLSSCEPLG NQPVEPLTMD NYFWGPTEPV ATEMVDKHRN
LYRAHFPVAG SYHWPNTGLY FVVRGPVTIE IEFCAWDQFL DQTVPQHSWM VAGPLFDIKA
KPGAVAAVYL PHFIALQGQH VDISLFQVAH IKEDGILMEK PASVEPHYIV LENPSFSPMG
VLQRMIHTAL CIPVISNVLL YYRLQSEEVN FHLYLIPSDC TVRKAIDDEE KKFQFFQIRK
PPPLTPLYLG SRYTVSGSDK LEIIPEELEL CYRSPGKPQL FSEFYVGHFV SGIRLQIKSK
DDETVVWKAL VKSGDLRPEA PLVSQAMTDA PTLLHFVDQH REDLVTRVTS VDTVLDKLHG
QVLSEEQYER VRAEPTNPDK MRKLFSFSKS WDWACKDQLY QALKVTHPHL TEDLWEK
//
