ID G1QC64_MYOLU Unreviewed; 593 AA.
AC G1QC64;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Nucleolar protein 56 {ECO:0000256|ARBA:ARBA00040742};
DE AltName: Full=Nucleolar protein 5A {ECO:0000256|ARBA:ARBA00041388};
GN Name=NOP56 {ECO:0000313|Ensembl:ENSMLUP00000021297.1};
OS Myotis lucifugus (Little brown bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Myotis.
OX NCBI_TaxID=59463 {ECO:0000313|Ensembl:ENSMLUP00000021297.1, ECO:0000313|Proteomes:UP000001074};
RN [1] {ECO:0000313|Ensembl:ENSMLUP00000021297.1, ECO:0000313|Proteomes:UP000001074}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSMLUP00000021297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NOP5/NOP56 family.
CC {ECO:0000256|ARBA:ARBA00009211}.
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DR EMBL; AAPE02032348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QC64; -.
DR STRING; 59463.ENSMLUP00000021297; -.
DR Ensembl; ENSMLUT00000027902.1; ENSMLUP00000021297.1; ENSMLUG00000027085.1.
DR eggNOG; KOG2573; Eukaryota.
DR GeneTree; ENSGT00940000153534; -.
DR HOGENOM; CLU_015495_4_0_1; -.
DR InParanoid; G1QC64; -.
DR OMA; DNYMFAK; -.
DR TreeFam; TF105713; -.
DR Proteomes; UP000001074; Unassembled WGS sequence.
DR GO; GO:0031428; C:box C/D RNP complex; IEA:InterPro.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0070761; C:pre-snoRNP complex; IEA:Ensembl.
DR GO; GO:0032040; C:small-subunit processome; IEA:Ensembl.
DR GO; GO:1990226; F:histone methyltransferase binding; IEA:Ensembl.
DR GO; GO:0030515; F:snoRNA binding; IEA:Ensembl.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:Ensembl.
DR Gene3D; 1.10.287.4070; -; 1.
DR Gene3D; 1.10.246.90; Nop domain; 1.
DR InterPro; IPR045056; Nop56/Nop58.
DR InterPro; IPR012974; NOP58/56_N.
DR InterPro; IPR042239; Nop_C.
DR InterPro; IPR002687; Nop_dom.
DR InterPro; IPR036070; Nop_dom_sf.
DR InterPro; IPR012976; NOSIC.
DR PANTHER; PTHR10894; NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58; 1.
DR PANTHER; PTHR10894:SF0; NUCLEOLAR PROTEIN 56; 1.
DR Pfam; PF01798; Nop; 1.
DR Pfam; PF08156; NOP5NT; 1.
DR SMART; SM00931; NOSIC; 1.
DR SUPFAM; SSF89124; Nop domain; 1.
DR PROSITE; PS51358; NOP; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001074}.
FT DOMAIN 291..409
FT /note="Nop"
FT /evidence="ECO:0000259|PROSITE:PS51358"
FT REGION 456..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 417..456
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 470..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 66255 MW; 677BAD5BB9A26C13 CRC64;
QVLLHVLFEH AVGYTLLALK EVEEISLLQP QVEECVLNLG KFHNIVRLVA FSPFASSQVA
LENVNAVSEG IVHEDLRLFL EYLPTKKKKV LLGVGDPKIG AAIQEELGYN CQTGGVIAEI
LRGVRLHFHN LVKGLTDVSA CKAQLGLGHS YSRAKVKFNV NRVDNMIIQS ISLLDQLDKD
INTFSMRVRE WYGYHFPELV KIINDNATYC RVAQFIGNRK ELNEEKLEEL EELTMDGAKA
KAILDASRSS MGMDISAIDL INIESFSSRV VSLSEYRQSL HTYLRSKMSQ VAPSLSALIG
EAVGARLIAH AGSLTNLAKY PASTVQILGA EKALFRALKT RGNTPKYGLI FHSTFIGRAA
AKNKGRISRY LANKCSIASR IDCFSEVPTS VFGEKLREQV EERLSFYETG VIPRKNLEVM
KEAMVQAEEA AAEITRKLEK QEKKRLKKEK KRLAAIALAS PENSSSTPEE CEETNEKPKK
KKKQKLQETP QENGTEDPPV SLPKPKKRKS FSKEEFVNND LETANNGNLP KRKKSLTKQE
PVSEPEEATN RSVPKKKRKL SLKEEPLSSG PEEAVSNKSS KKKKKLQKLA QED
//
