ID G1QHS1_NOMLE Unreviewed; 788 AA.
AC G1QHS1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=SH3 and PX domains 2B {ECO:0000313|Ensembl:ENSNLEP00000000458.2};
GN Name=SH3PXD2B {ECO:0000313|Ensembl:ENSNLEP00000000458.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000000458.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000000458.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000000458.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the SH3PXD2 family.
CC {ECO:0000256|ARBA:ARBA00009628}.
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DR EMBL; ADFV01075660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075663; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075667; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01075669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QHS1; -.
DR STRING; 61853.ENSNLEP00000000458; -.
DR Ensembl; ENSNLET00000000487.2; ENSNLEP00000000458.2; ENSNLEG00000000384.2.
DR eggNOG; KOG4773; Eukaryota.
DR GeneTree; ENSGT00940000158396; -.
DR HOGENOM; CLU_013051_1_0_1; -.
DR InParanoid; G1QHS1; -.
DR OMA; PMIPTKH; -.
DR TreeFam; TF329347; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0060348; P:bone development; IEA:Ensembl.
DR GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0072657; P:protein localization to membrane; IEA:Ensembl.
DR GO; GO:0006801; P:superoxide metabolic process; IEA:Ensembl.
DR CDD; cd06888; PX_FISH; 1.
DR CDD; cd12075; SH3_Tks4_1; 1.
DR CDD; cd12076; SH3_Tks4_2; 1.
DR CDD; cd12078; SH3_Tks4_3; 1.
DR CDD; cd12018; SH3_Tks4_4; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 4.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037961; SH3PXD2_PX.
DR InterPro; IPR035477; SH3PXD2B_SH3_1.
DR InterPro; IPR035478; SH3PXD2B_SH3_2.
DR InterPro; IPR035479; SH3PXD2B_SH3_3.
DR InterPro; IPR035480; SH3PXD2B_SH3_4.
DR PANTHER; PTHR15706:SF2; BUD EMERGENCE PROTEIN 1; 1.
DR PANTHER; PTHR15706; SH3 MULTIPLE DOMAIN; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 4.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 4.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..104
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 127..186
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 196..255
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 343..402
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 727..788
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 102..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..647
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87976 MW; 2B22BA302772C5FB CRC64;
VYIIRVTWSS GSTEAIYRRY SKFFDLQMQM LDKFPMEGGQ KDPKQRIIPF LPGKILFRRS
HIRDVAVKRL IPIDEYCKAL IQLPPYISQC DEVLQFFETR PEDLNPPKEE HIGKKKSGGD
QTSADPMVLE QYVVVANYQK QESSEISLSV GQVVDIIEKN ESGWWFVSTA EEQGWVPATC
LEGQDGVQDE FSLQPEEEEK YTVIYPYTAR DQDEMNLERG AVVEVIQKNL EGWWKIRYQG
KEGWAPASYL KKNSGEPLPP KPGPGSPSHP GALDLDGVSR QQNAVGREKE LLSSQRDGRF
EGRPVPDGDA KQRSPKMRQR PPPRRDMTIP RGLNLPKPPI PPQVEEEYYT IAEFQTTIPD
GISFQAGLKV EVIEKNLSGW WYIQIEDKEG WAPATFIDKY KKTSNASRPN FLAPLPHEVT
QLRLGEAAAP ENNTGSEATG PSRPLPDAPH GAMDSGLPWS KDWKGSKDVL RKASSDMSAS
AGYEEISDPD VEEKPSLPPR KESIIKSEGE LLERERQRTE QLRGPAPKPP GMILPMMPAK
HTPPARDSRR PEPKPDKSKL FQLKNDMGLE CGHKVLAKEV KKPNLRPISK SKTDLPEEKP
DATPQNPFLK SRPQVRPKPA PVPLQEAPQQ RPVVPPRRPP PPKKTSSSSR PLPEVRGPQC
EGHESRAAPT PARALLVPPK AKPFLSNSLG GQDDTRGKGS LGPRGTGKIG ENREKAAAAS
VPNADGLKDS LYVAVADFEG DKDTSSFQEG TVFEVREKNS SGWWFCQVLS GAPSWEGWIP
SNYLRKKP
//
