ID G1QP67_NOMLE Unreviewed; 61 AA.
AC G1QP67;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
GN Name=LOC100605650 {ECO:0000313|Ensembl:ENSNLEP00000002733.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000002733.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000002733.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000002733.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Metallothioneins have a high content of cysteine residues
CC that bind various heavy metals; these proteins are transcriptionally
CC regulated by both heavy metals and glucocorticoids.
CC {ECO:0000256|ARBA:ARBA00002597}.
CC -!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.
CC {ECO:0000256|ARBA:ARBA00007283, ECO:0000256|RuleBase:RU000621}.
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DR EMBL; ADFV01012986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003263129.1; XM_003263081.3.
DR AlphaFoldDB; G1QP67; -.
DR STRING; 61853.ENSNLEP00000002733; -.
DR Ensembl; ENSNLET00000002879.2; ENSNLEP00000002733.3; ENSNLEG00000002306.2.
DR GeneID; 100605650; -.
DR KEGG; nle:100605650; -.
DR GeneTree; ENSGT00950000182967; -.
DR HOGENOM; CLU_2637455_0_0_1; -.
DR InParanoid; G1QP67; -.
DR OMA; FCCPVGC; -.
DR TreeFam; TF336054; -.
DR Proteomes; UP000001073; Chromosome 2.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070887; P:cellular response to chemical stimulus; IEA:UniProt.
DR GO; GO:0010035; P:response to inorganic substance; IEA:UniProt.
DR Gene3D; 4.10.10.10; Metallothionein Isoform II; 1.
DR InterPro; IPR017854; Metalthion_dom_sf.
DR InterPro; IPR023587; Metalthion_dom_sf_vert.
DR InterPro; IPR000006; Metalthion_vert.
DR InterPro; IPR018064; Metalthion_vert_metal_BS.
DR PANTHER; PTHR23299; METALLOTHIONEIN; 1.
DR PANTHER; PTHR23299:SF63; METALLOTHIONEIN 1H-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00131; Metallothio; 1.
DR PRINTS; PR00860; MTVERTEBRATE.
DR SUPFAM; SSF57868; Metallothionein; 1.
DR PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000621};
KW Metal-thiolate cluster {ECO:0000256|ARBA:ARBA00022851,
KW ECO:0000256|RuleBase:RU000621};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
SQ SEQUENCE 61 AA; 6066 MW; 69817B572ECBD1D9 CRC64;
MDPNCSCAAG VSCACAGSCK CKECKCTSCK KSCCSCCPVG CVKCAQGCIC KGVSEKCSCC
A
//
