ID G1QQQ5_NOMLE Unreviewed; 446 AA.
AC G1QQQ5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Calcium-binding and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040931};
DE AltName: Full=Nuclear domain 10 protein NDP52 {ECO:0000256|ARBA:ARBA00041519};
GN Name=CALCOCO2 {ECO:0000313|Ensembl:ENSNLEP00000003273.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003273.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003273.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003273.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, autophagosome
CC membrane {ECO:0000256|ARBA:ARBA00037854}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037854}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the CALCOCO family.
CC {ECO:0000256|ARBA:ARBA00037963}.
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DR RefSeq; XP_003278790.1; XM_003278742.3.
DR AlphaFoldDB; G1QQQ5; -.
DR Ensembl; ENSNLET00000003439.2; ENSNLEP00000003273.2; ENSNLEG00000002619.3.
DR GeneID; 100581011; -.
DR KEGG; nle:100581011; -.
DR CTD; 10241; -.
DR eggNOG; ENOG502QT1M; Eukaryota.
DR GeneTree; ENSGT00950000183025; -.
DR OrthoDB; 3062393at2759; -.
DR TreeFam; TF329501; -.
DR Proteomes; UP000001073; Unplaced.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd21968; Zn-C2H2_CALCOCO2; 1.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR PANTHER; PTHR31915:SF4; CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF17751; SKICH; 1.
DR PROSITE; PS51905; ZF_UBZ1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU01253}.
FT DOMAIN 419..444
FT /note="UBZ1-type"
FT /evidence="ECO:0000259|PROSITE:PS51905"
FT COILED 142..348
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 446 AA; 52369 MW; 5867BA95B76C13A1 CRC64;
MEKTIEDPPT SAILLDHCHF SQVIFNSVEK FYIPGGDVTC HYTLTQHFIP RRKDWIGIFR
VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK DDEYYQFCYV DQDGVVRGAS
IPFQFRPENE EDILVVTTQG EVEEIEQHNK ELCKENQELK DSCVSLQKQN SDMQAELQKK
QEELETLQSI NKKLELKVKQ QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ
EKEMEKLVQG DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK HNETTAMKKQ
QELMDENFDL SKRLSENKMM YNALQREKER LEGENDLLKR ENSRLLSYMG LDFDSLPYQV
PASDERGAGQ NPGLVYGNPY SGIQESSSPS LLSIKKCPIC KSDDICDHTW EQQQMQSLCL
NCPVCDKIFP ATEKQIFEDH VFCHSL
//
