ID G1QRY1_NOMLE Unreviewed; 240 AA.
AC G1QRY1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=G1/S-specific cyclin-D2 {ECO:0000256|ARBA:ARBA00039574};
GN Name=CCND2 {ECO:0000313|Ensembl:ENSNLEP00000003699.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000003699.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000003699.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000003699.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}. Nucleus
CC membrane {ECO:0000256|ARBA:ARBA00004126}.
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DR EMBL; ADFV01078296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01078297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1QRY1; -.
DR STRING; 61853.ENSNLEP00000003699; -.
DR Ensembl; ENSNLET00000003882.3; ENSNLEP00000003699.3; ENSNLEG00000003059.3.
DR eggNOG; KOG0235; Eukaryota.
DR eggNOG; KOG0656; Eukaryota.
DR GeneTree; ENSGT00940000155180; -.
DR HOGENOM; CLU_499611_0_0_1; -.
DR InParanoid; G1QRY1; -.
DR OMA; CLEMDTN; -.
DR TreeFam; TF101004; -.
DR Proteomes; UP000001073; Chromosome 23.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0097129; C:cyclin D2-CDK4 complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0071481; P:cellular response to X-ray; IEA:Ensembl.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0007616; P:long-term memory; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd20577; CYCLIN_CCND2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR PANTHER; PTHR10177:SF66; G1_S-SPECIFIC CYCLIN-D2; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 4: Predicted;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 105..235
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT REGION 215..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27496 MW; 03D139A118EC7E18 CRC64;
MELLCCEVDP VRRAVRDRNL LQDDRVLQNL LTIEERYLPQ CSYFKCVQKD IQPYMRRMVA
TWMLETSPLT AEKLCIYTDN SIKPQELLEW ELVVLGKLKW NLAAVTPHDF IEHILRKLPQ
QREKLSLIRK HAQTFIALCA TDFKFAMYPP SMIATGSVGA AICGLQQDEE VSSLTCDALT
ELLAKITNTD VDCLKACQEQ IEAVLLNSLQ QYRQDQRDGS KSEDELDQAS TPTDVRDIDL
//
