ID G1R4W8_NOMLE Unreviewed; 1117 AA.
AC G1R4W8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Myosin IB {ECO:0000313|Ensembl:ENSNLEP00000008240.3};
GN Name=MYO1B {ECO:0000313|Ensembl:ENSNLEP00000008240.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008240.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008240.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008240.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; ADFV01059343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01059352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R4W8; -.
DR STRING; 61853.ENSNLEP00000008240; -.
DR Ensembl; ENSNLET00000008629.3; ENSNLEP00000008240.3; ENSNLEG00000006735.3.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000155752; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; G1R4W8; -.
DR OMA; PLYGNEY; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000001073; Chromosome 22a.
DR GO; GO:0005884; C:actin filament; IEA:Ensembl.
DR GO; GO:0005903; C:brush border; ISS:UniProtKB.
DR GO; GO:0071944; C:cell periphery; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR GO; GO:0030175; C:filopodium; ISS:UniProtKB.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0032588; C:trans-Golgi network membrane; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR GO; GO:0000146; F:microfilament motor activity; ISS:UniProtKB.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISS:UniProtKB.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.
DR GO; GO:0051017; P:actin filament bundle assembly; ISS:UniProtKB.
DR GO; GO:0030048; P:actin filament-based movement; ISS:UniProtKB.
DR GO; GO:0006892; P:post-Golgi vesicle-mediated transport; IEA:Ensembl.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF277; UNCONVENTIONAL MYOSIN-IB; 1.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50096; IQ; 5.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 15..682
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 933..1117
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 559..581
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 108..115
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1117 AA; 129848 MW; A2B7EA617FE2E2ED CRC64;
MAKMEVKTSL LDNMIGVGDM VLLEPLNEET FINNLKKRFD HSEIYTYIGS VVISVNPYRS
LPIYSPEKVE EYRNRNFYEL SPHIFALSDE AYRSLRDQDK DQCILITGES GAGKTEASKL
VMSYVAAVCG KGAEVNQVKE QLLQSNPVLE AFGNAKTVRN DNSSRFGKYM DIEFDFKGDP
LGGVISNFLV KKFRILKHLY KSLFLCVRDF SRYNYLSLDS AKVNGVDDAA NFRTVRNAMQ
IVGFMDHEAE SVLAVVAAVL KLGNIEFKPE SRVNGLDESK IKDKNELKEI CELTGIDQSV
LERAFSFRTV EAKQEKVSTT LNVAQAYYAR DALAKNLYSR LFSWLVNRIN ESIKAQTKVR
KKVMGVLDIY GFEIFEDNSF EQFIINYCNE KLQQIFIELT LKEEQEEYIR EDIEWTHIDY
FNNAIICDLI ENNTNGILAM LDEECLRPGT VTDETFLEKL NQVCATHQHF ESRMSKCSRF
LNDTSLPHSC FRIQHYAGKV LYQVEGFVDK NNDLLYRDLS QAMWKASHAL IKSLFPEGNP
AKINLKRPPT AGSQFKASVA TLMKNLQTKN PNYIRCIKPN DKKAAHIFNE ALVCHQIRYL
GLLENVRVRR AGYAFRQAYE PCLERYKMLC KQTWPHWKGP ARSGVEVLFN ELEIPVEEYS
FGRSKIFIRN PRTLFKLEDL RKQRLEDLAT LIQKIYRGWK CRTHFLLMKK SQIVIAAWYR
RYAQQKRYQQ TKSSALVIQS YIRGWKARKI LRELKHQKRC KEAVTTIAAY WHGTQARREL
RRLKEEARNK HAIAVIWAYW LGSKARRELK RLKEEARRKH AVAVIWAYWL GLKVRREYRK
FFRANAGKKI YEFTLQRIVQ KYFLEMKNKM PSLSPIDKNW PSRPYLFLDS THKELKRIFH
LWRCKKYRDQ FTDQQKLIYE EKLEASELFK DKKALYPSSV GQPFQGAYLE INKNPKYKKL
KDAIEEKIII AEVVNKINRA NGKSTSRIFL LTNNNLLLAD QKSGQIKSEV PLVDVTKVSM
SSQNDGFFAV HLKEGSEAAS KGDFLFSSDH LIEMATKLYR TTLSQTKQKL NIEISDEFLV
QFRQDKVCVK FIQGNQKNGS VPTCKRKNNR LLEVAVP
//
