ID G1R5I8_NOMLE Unreviewed; 1113 AA.
AC G1R5I8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RNA binding motif protein 6 {ECO:0000313|Ensembl:ENSNLEP00000008460.2};
GN Name=RBM6 {ECO:0000313|Ensembl:ENSNLEP00000008460.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008460.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000008460.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000008460.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01173208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173210; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173214; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173215; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01173217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1R5I8; -.
DR STRING; 61853.ENSNLEP00000008460; -.
DR Ensembl; ENSNLET00000008860.2; ENSNLEP00000008460.2; ENSNLEG00000006932.2.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00940000157976; -.
DR HOGENOM; CLU_291499_0_0_1; -.
DR InParanoid; G1R5I8; -.
DR OMA; REVGSCM; -.
DR TreeFam; TF315789; -.
DR Proteomes; UP000001073; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd16163; OCRE_RBM6; 1.
DR CDD; cd12314; RRM1_RBM6; 1.
DR CDD; cd12563; RRM2_RBM6; 1.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR035617; RBM6_OCRE.
DR InterPro; IPR034123; RBM6_RRM1.
DR InterPro; IPR034125; RBM6_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF22; RNA-BINDING PROTEIN 6; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 449..529
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1041..1087
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 406..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 998..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..281
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..340
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 820..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 865..879
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1042
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1113 AA; 127431 MW; E1625C15641B2767 CRC64;
MWGDSRPANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR DSLPFDFQGH
SGPPFANVEE HSFSYGARDG PHGDYRGGEG PGHDFRGGDF SSSDFRLDFR VGTYILGIFG
IEKDTMDYRG GDGTSMDYRG REAHHMNYRD RDAHAVDFRG RDAPPSDFRG RGTYDLDFRG
RDGSHADFRG RDLSDLDFRA REQSRSDFRN RDVSDLDFRE KDGTQVDFRG RGSGTTDLDF
RDRDTPHSDF RGRHRSRTDQ DFRGREMGSC MEFKDREMPP VDPNILDYIQ PSTQDREHSG
MNVNRREEST HDHTIERPAF GIQKGEFEHS ETREGETQGV AFEHESPADF QNSQSPVQDQ
DKSQLSGGEQ QNSDAGLFKE EGGLDFLGRQ DTDYRSMEYR DVDHRLPGSQ MFGYGQSKSF
PEGKTARDAQ RDLQDQDYRT GPSEEKPSRL IRLSGVPENA TKEEILNAFR TPDGMLVKNL
QLKEYNTGYD YGYVCVEFSL LEDAIGCMEA NQGTLMIQDK EVTLEYVPSL DFWYCKRCKA
SIGGHRSSCS FCKNPREVTE AKQELITYPQ PQKTSIPAPL EKQPNQPLRP ADKEPEPRKR
EEGQESRLGH QKREAERYLP PSRREGPTFR RDREKESWSG ETRQDGESKT IMLKRIYRST
PPEVIVEVLE PYVRLTTANV RIIKNRTGPM GHTYGFIDLD SHAEALRVVK ILQNLDPPFS
IDGKMVAVNL ATGKRRNDSG DHSDHMHYYQ GKKYFRDRRG GGRNSDWSSD TNRQGQQSSS
DCYIYDSATG YYYDPLAGTY YDPNTQQEVY VPQDPGLPEE EEIKEKKPTS QGKSSSKKEM
SKRDGKEKKD RGVTRFQENA SEGKASAEDV FKKPLPPTVK KEESPPPPKV VNPLIGLLGE
YGGDSDYEEE EEEEQTPPPQ PRTAQPQKRE EQTKKENEED KLTDWNKLAC LLLFPIIEVL
IKHQQLSDLH RQNLEIHRKI KQSEQELAYL ERREREGKFK ERGNDRREKL QSFDSPERKR
IKYSRETDSD RKLVDKEDID TSSKGGCVQQ ATGWRKGTGL GYGHPGLASS EEAEGRMRGP
SVGAPGRTSK RQSNETYRDA VRRVMFARYK ELD
//
