ID   G1R5K6_NOMLE            Unreviewed;       950 AA.
AC   G1R5K6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Protein phosphatase 4 regulatory subunit 1 {ECO:0000313|Ensembl:ENSNLEP00000008478.1};
GN   Name=PPP4R1 {ECO:0000313|Ensembl:ENSNLEP00000008478.1};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000008478.1, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000008478.1, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000008478.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; ADFV01007843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01007844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01007845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01007846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003262126.1; XM_003262078.3.
DR   AlphaFoldDB; G1R5K6; -.
DR   STRING; 61853.ENSNLEP00000008478; -.
DR   Ensembl; ENSNLET00000008879.3; ENSNLEP00000008478.1; ENSNLEG00000006952.3.
DR   GeneID; 100601483; -.
DR   KEGG; nle:100601483; -.
DR   CTD; 9989; -.
DR   eggNOG; KOG0211; Eukaryota.
DR   GeneTree; ENSGT00950000183066; -.
DR   HOGENOM; CLU_009128_1_1_1; -.
DR   InParanoid; G1R5K6; -.
DR   OMA; CYIHNDS; -.
DR   OrthoDB; 1367932at2759; -.
DR   TreeFam; TF105560; -.
DR   Proteomes; UP000001073; Chromosome 4.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR033461; WRNPLPNID.
DR   PANTHER; PTHR10648; SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10648:SF8; SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1; 1.
DR   Pfam; PF02985; HEAT; 1.
DR   Pfam; PF15017; WRNPLPNID; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REPEAT          132..170
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          173..212
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   DOMAIN          453..475
FT                   /note="Putative WW-binding"
FT                   /evidence="ECO:0000259|Pfam:PF15017"
FT   REGION          326..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          473..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        334..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   950 AA;  106971 MW;  211092598E455167 CRC64;
     MADLSLLQED LQEDADGFGV DDYSSESDVI IIPSALDFVS QDEMLTPLGR LDKYAASENV
     FNRQMVARSL LDTLREVCDD ERDCIAVLER ISRLADDSEP TVRAELMEQV PHIALFCQEN
     RPSIPYAFSK FLLPIVVRYL ADQNNQVRKT SQAALLALLE QELIERFDVE TKVCPVLIEL
     TAPDSNDDVK TEAVAIMCKM APMVGKDITE RLILPRFCEM CCDCRMFHVR KVCAANFGDI
     CSVVGQQATE EMLLPRFFQL CSDNVWGVRK ACAECFMAVS CATCQEIRRT KLSALFINLI
     SDPSRWVRQA AFQSLGPFIS TFANPSSSGQ YFKEESKSSE ETSVENKNRT RDQEAPEDVQ
     VRPEDPPSDL SVSNSSVILE NTMEDHAAEA SGKPLGEISV PLDSSLLCTL SSESHQEAAS
     NENDKKSGNY KFVLRPEVGT TSQDSALLDQ ELYNSFHFWR TPLPEIDLDI ELEQNSGGKP
     SPEGPEEASE GPVPSSPNIT MATRKELEEM IENLEPHIDD PDVKAQVEVL SAALRASSLD
     VHEETINIEK RSDLQDELDI NELPNCKINQ EDSVPLISNA VENMDSTLPY IHNDSDLSNN
     SSFSPDEERR TKIQDVVPQA LLDQYLSMTD PSRAQTVDTE IAKHCAYSLP GVALTLGRQN
     WHCLRETYET LASDMQWKVR RTLAFSIHEL AVILGDQLTA ADLVPIFNGF LKDLDEVRIG
     VLKHLHDFLK LLHIDKRREY LYQLQEFLVT DNSRNWRFRA ELAEQLILLL ELYSPRDVYD
     YLRPIALNLC ADKVSSVRWI SYKLVSEMVK KLHAATPPTF GVDLINELVE NFGRCPKWSG
     RQAFVFVCQT VIEDDCLPMD QFAVHLMPHL LTLANDRVPN VRVLLAKTLR QTLLEKDYFL
     ASASCHQEAV EQTIMALQMD RDSDVKYFAS IHPASTKISE DAMSTASSTY
//