ID G1RAE3_NOMLE Unreviewed; 588 AA.
AC G1RAE3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Growth factor receptor bound protein 10 {ECO:0000313|Ensembl:ENSNLEP00000010190.2};
GN Name=GRB10 {ECO:0000313|Ensembl:ENSNLEP00000010190.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000010190.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000010190.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000010190.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
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DR EMBL; ADFV01085114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085115; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085116; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01085119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012352424.1; XM_012496970.1.
DR AlphaFoldDB; G1RAE3; -.
DR Ensembl; ENSNLET00000010690.2; ENSNLEP00000010190.2; ENSNLEG00000008302.2.
DR eggNOG; KOG3751; Eukaryota.
DR GeneTree; ENSGT00940000155909; -.
DR HOGENOM; CLU_023207_0_1_1; -.
DR TreeFam; TF317511; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16141; RA_GRB10; 1.
DR CDD; cd10415; SH2_Grb10; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR015042; BPS-dom.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR035037; Grb10_SH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10; 1.
DR Pfam; PF08947; BPS; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 160..244
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 284..393
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 487..583
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 76..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 66459 MW; 09D33B5E29E51BA9 CRC64;
MQAAGPVFRS KDKVEQTPRS QQDPAGPGLP AQSDRLANHQ EDDVDLEALV NDMNASLESL
YSACSMQSDT VPLLQNGQHA RSQPRASGPP RSVQPQVSPR QRVQRSQPVH ILAVRRLQEE
DQQFRTSSLP AIPNPFPELC GPGSPPVLTP GSLPPSQAAA KQDVKVFSED GTSKVVEILA
DMTARDLCQL LVYKSHCVDD NSWTLVEHHP HLGLERCLED HELVVQVEST MASESKFLFR
KNYAKYEFFK NPMNFFPEQM VTWCQQSNGS QTQLLQNFLN SSSCPEIQGF LHVKELGKKS
WKKLYVCLRR SGLYCSTKGT SKEPRHLQLL ADLEDSNIFS LIAGRKQYNA PTDHGLCIKP
NKVRNETKEL RLLCAEDEQT RTCWMTAFRL LKYGMLLYQN YRIPQQRKAL LSPFSTPVRS
VSENSLVAMD FSGQTGRVIE NPAEAQSAAL EEGHAWRKRS TRMNILGSQS PLHPSTLSTV
IHRTQHWFHG RISREESHRI IKQQGLVDGL FLLRDSQSNP KAFVLTLCHH QKIKNFQILP
CEDDGQTFFS LDDGNTKFSD LIQLVDFYQL NKGVLPCKLK HHCIRVAL
//
