ID G1RF32_NOMLE Unreviewed; 589 AA.
AC G1RF32;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Serine/threonine-protein phosphatase {ECO:0000256|RuleBase:RU004273};
DE EC=3.1.3.16 {ECO:0000256|RuleBase:RU004273};
GN Name=PPEF1 {ECO:0000313|Ensembl:ENSNLEP00000011832.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011832.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011832.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011832.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:83421; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001512};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482,
CC ECO:0000256|RuleBase:RU004273};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|ARBA:ARBA00008294, ECO:0000256|RuleBase:RU004273}.
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DR EMBL; ADFV01194607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194613; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194615; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01194616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RF32; -.
DR Ensembl; ENSNLET00000012414.3; ENSNLEP00000011832.2; ENSNLEG00000009696.3.
DR eggNOG; KOG0377; Eukaryota.
DR GeneTree; ENSGT00940000159830; -.
DR HOGENOM; CLU_012603_1_0_1; -.
DR TreeFam; TF313342; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0050906; P:detection of stimulus involved in sensory perception; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR013235; PPP_dom.
DR InterPro; IPR012008; Ser/Thr-Pase_EF-hand_contain.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF08321; PPP5; 1.
DR PIRSF; PIRSF000912; PPEF; 2.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00054; EFh; 3.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004273};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 502..537
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 542..577
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
SQ SEQUENCE 589 AA; 68504 MW; 3B60AE324A8EE8A4 CRC64;
MGCSSSSVKT RRSETSLRAA LIIQNWYRGY KARLKARQHY ALTIFQSIEY ADEQSQMQLS
TFFSFMLENY THKEELELRN QSLESEQDMR DRRDYVDLID VPDSYNGPRL QFPLTCTDID
LLLEAFKEQQ ILHAHYVLEV LFETKKLLKQ MPNFTHIQTS PSKEVTICGD LHGKLDDLFL
IFYKNGLPSE RNPYVFNGDF VDRGRNSIEI LMILCVSFLV YPNDLHLNRG NHEDFMMNLR
YGFTKEILHK YKLHGKRILQ ILEELYAWLP IGTIIDDEVL VIHGGISETT DLNLLHRVER
NKMKSVLIPP TETSRDHDTD SKHNKVGVTF NAHGRIKTNG SPIEHLTKRE WEQVVTIFSA
SNYYEEGSNR GAYIKLCSGT TPRFFQYQVT KATCFQPLRQ RVHTMENSAI KILRERVISR
KSDLTRAFQL QDHRKSGKLS VSQWAFCMEN ILGLNLPWRS LSSNLVNIDQ NGNVEYMSSF
QNIHIEKPVQ EAHSTLVETL YRYRSDLEII FNAIDTDHSG LISMEEFRAM WKLFSSHYSV
LIDDSQVNKL ANIMDLNKDG SIDFNEFLKA FYVVHRYGDL MKPDVSNLG
//
