ID G1RFD3_NOMLE Unreviewed; 337 AA.
AC G1RFD3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Carbonic anhydrase 14 {ECO:0000313|Ensembl:ENSNLEP00000011933.2};
GN Name=CA14 {ECO:0000313|Ensembl:ENSNLEP00000011933.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000011933.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000011933.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000011933.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC {ECO:0000256|ARBA:ARBA00010718}.
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DR EMBL; ADFV01183055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RFD3; -.
DR STRING; 61853.ENSNLEP00000011933; -.
DR Ensembl; ENSNLET00000012516.2; ENSNLEP00000011933.2; ENSNLEG00000009787.2.
DR eggNOG; KOG0382; Eukaryota.
DR GeneTree; ENSGT00940000156893; -.
DR HOGENOM; CLU_039326_1_2_1; -.
DR InParanoid; G1RFD3; -.
DR OMA; HKNTRYA; -.
DR OrthoDB; 49814at2759; -.
DR TreeFam; TF316425; -.
DR Proteomes; UP000001073; Chromosome 12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd03126; alpha_CA_XII_XIV; 1.
DR Gene3D; 3.10.200.10; Alpha carbonic anhydrase; 1.
DR InterPro; IPR001148; CA_dom.
DR InterPro; IPR036398; CA_dom_sf.
DR InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR PANTHER; PTHR18952; CARBONIC ANHYDRASE; 1.
DR PANTHER; PTHR18952:SF84; CARBONIC ANHYDRASE 14; 1.
DR Pfam; PF00194; Carb_anhydrase; 1.
DR SMART; SM01057; Carb_anhydrase; 1.
DR SUPFAM; SSF51069; Carbonic anhydrase; 1.
DR PROSITE; PS51144; ALPHA_CA_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..337
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030171703"
FT TRANSMEM 290..312
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..278
FT /note="Alpha-carbonic anhydrase"
FT /evidence="ECO:0000259|PROSITE:PS51144"
SQ SEQUENCE 337 AA; 37613 MW; 0E9A96DCC5122664 CRC64;
MLFSALLLEV IWILAADGGQ HWTYEGPHGQ DHWPASYPEC GNNAQSPIDI QTDSVTFDPE
LPALQPHGYD QPGTEPLDLH NNGHTVQLSL PSTLYLGGLP RKYVAAQLHL HWGQKGSPEG
SEHQINSEAT VAELHIVHYD SDSYDSLSEA AERPQGLAVL GILIEVGETK NIAYEHILSH
LHEVRHKDQK TSVPPFNLRE LLPPQLGQYF RYNGSLTTPP CYQSVLWTVF YRRSQISMEQ
LEKLQGTLFS TEEGPSKLLV QNYRAPQPLN QRMVFASFIQ AGSLYTTGEM LSLGVGILVG
CLCLLLAVYF IARKIRKKRL ENRKSVVFTS AQATTEA
//
