ID G1RNV6_NOMLE Unreviewed; 974 AA.
AC G1RNV6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=BicC family RNA binding protein 1 {ECO:0000313|Ensembl:ENSNLEP00000014920.3};
GN Name=BICC1 {ECO:0000313|Ensembl:ENSNLEP00000014920.3};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000014920.3, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000014920.3, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000014920.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the BicC family.
CC {ECO:0000256|ARBA:ARBA00007662}.
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DR EMBL; ADFV01179990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179992; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179996; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179998; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01179999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258298.1; XM_003258250.2.
DR AlphaFoldDB; G1RNV6; -.
DR STRING; 61853.ENSNLEP00000014920; -.
DR Ensembl; ENSNLET00000015665.3; ENSNLEP00000014920.3; ENSNLEG00000012284.3.
DR GeneID; 100589900; -.
DR KEGG; nle:100589900; -.
DR CTD; 80114; -.
DR eggNOG; KOG2208; Eukaryota.
DR eggNOG; KOG4374; Eukaryota.
DR GeneTree; ENSGT00940000156276; -.
DR HOGENOM; CLU_008040_0_0_1; -.
DR InParanoid; G1RNV6; -.
DR OMA; PDNDTPY; -.
DR OrthoDB; 2906718at2759; -.
DR TreeFam; TF323767; -.
DR Proteomes; UP000001073; Chromosome 18.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR CDD; cd22420; KH-I_BICC1_rpt1; 1.
DR CDD; cd22421; KH-I_BICC1_rpt2; 1.
DR CDD; cd22422; KH-I_BICC1_rpt3; 1.
DR CDD; cd09520; SAM_BICC1; 1.
DR Gene3D; 3.30.310.270; -; 2.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR047549; BICC1_KH-I_rpt1.
DR InterPro; IPR047554; BICC1_KH-I_rpt2.
DR InterPro; IPR047553; BICC1_KH-I_rpt3.
DR InterPro; IPR037974; BICC1_SAM_dom.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR10627:SF78; PROTEIN BICAUDAL C HOMOLOG 1; 1.
DR PANTHER; PTHR10627; SCP160; 1.
DR Pfam; PF00013; KH_1; 2.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00322; KH; 3.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 873..936
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 787..816
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 104900 MW; B8C6D905B3ADD96F CRC64;
MAAQGEPGYL AAQSDPGSNS ERSTDSPMPG SEDDLVAGAT LHSPEWSEER FRVDRKKLEA
MLQAAAEGKG RSGEDFFQKI MEETNTQIAW PSKLKIGAKS KKDPHIKVSG KKEDVKEAKE
MIMSVLDTKS NRVTLKMDVS HTEHSHVIGK GGNNIKKVME ETGCHIHFPD SNRNNQAEKS
NQVSIAGQPA GVESARVRIR ELLPLVLMFE LPIAGILQPV PDPNSPSIQH ISQTYNISVS
FKQRSRMYGA TVIVRGSQNN TSAVKEGTAM LLEHLAGSLA SAIPVSTQLD IAAQHHLFMM
GRNGSNIKHI MQRTGAQIHF PDPSNPQKKS TVYLQGTIES VCLARQYLMG CLPLVLMFDM
KEEIEVDPQF IAQLMEQLDV FISIKPKPKQ PSKSVIVKSV ERNALNMYEA RKCLLGLESS
GVTIATSPSP ASCPAGLACP SLDILASAGL GLTGLGLLGP TTLSLNTSTT PNSLLNALNS
SVSPLRSPSS GTPSPTLWAP PLANTSSATG FSAIPHLMIP STAQATLTNI LLSGVPTYGH
TAPSPPPGLT PVDVHINSMQ TKGKKISAAL NGHAQSPNIK YGAISTSSLG EKVLSANHGD
PSIQTSGSEQ TSPKSSPTEG CNDAFVEVGM PRSPSHSGNA GDLKQMLCPS KVSCAKRQTV
ELLQGTKNSH LHSTDRLLSD PELSATESPL ADKKAPGSER AAERAAAAQQ NSERAHLAPR
SSYVNMQAFD YEQKKLLATK AMLKKPVVTE VRTPTNTWSG LGFSKSMPAE TIKELRRANH
VSYKPTMTTT YEGSSMSLSR SNSREHLGSG SESANWRDRN GIGPGSHSEF AASIGSPKRK
QNKSTEHYLS SSNYMDCISS LTGSNGCNLN SSFKGSDLPE LFSKLGLGKY TDVFQQQEID
LQTFLTLTDQ DLKELGITTF GARRKMLLAI SELNKNRRKL FELTNARTSF LEGGASGRLP
RQYHSDIASV SGRW
//
