ID G1RR54_NOMLE Unreviewed; 1864 AA.
AC G1RR54;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Plexin A4 {ECO:0000313|Ensembl:ENSNLEP00000015718.2};
GN Name=PLXNA4 {ECO:0000313|Ensembl:ENSNLEP00000015718.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000015718.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000015718.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000015718.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; ADFV01196396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196397; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196400; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196401; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 61853.ENSNLEP00000015718; -.
DR Ensembl; ENSNLET00000016518.2; ENSNLEP00000015718.2; ENSNLEG00000012960.3.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01050000244850; -.
DR HOGENOM; CLU_001436_2_0_1; -.
DR InParanoid; G1RR54; -.
DR OMA; HESRWLE; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000001073; Chromosome 13.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0021793; P:chemorepulsion of branchiomotor axon; IEA:Ensembl.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0021612; P:facial nerve structural organization; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR GO; GO:0021784; P:postganglionic parasympathetic fiber development; IEA:Ensembl.
DR GO; GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR GO; GO:0050923; P:regulation of negative chemotaxis; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR GO; GO:0097492; P:sympathetic neuron axon guidance; IEA:Ensembl.
DR GO; GO:0021637; P:trigeminal nerve structural organization; IEA:Ensembl.
DR GO; GO:0021644; P:vagus nerve morphogenesis; IEA:Ensembl.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11274; Sema_plexin_A4; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 2.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 2.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1864
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014153520"
FT TRANSMEM 1208..1230
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..507
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1234..1261
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1864 AA; 209258 MW; 4D5DFF75B88DDD22 CRC64;
MKAMPWNWTC LLSHLLMVGM GSSTLLTRQP APLSQKQRSF VTFRGEPAEG FNHLVVDERT
GHIYLGAVNR IYKLSSDLKV LVTHETGPDE DNPKCYPPRI VQTCNEPLTT TNNVNKMLLI
DYKENRLIAC GSLYQGICKL LRLEDLFKLG EPYHKKEHYL SGVNESGSVF GVIVSYSNLD
DKLFIATAVD GKPEYFPTIS SRKLTKNSEA DGMFAYVFHD EFVASMIKIP SDTFTIIPDF
DIYYVYGFSS GNFVYFLTLQ PEMVSPPGST TKEQVYTSKL VRLCKEDTAF NSYVEVPIGC
ERSGVEYRLL QAAYLSKAGA VLGRTLGVHP DDDLLFTVFS KGQKRKMKSL DESALCIFIL
KQINDRIKER LQSCYRGEGT LDLAWLKVKD IPCSSALLTI DDNFCGLDMN APLGVSDMVR
GIPVFTEDRD RMTSVIAYVY KNHSLAFVGT KSGKLKKIRV DGPRGNALQY ETVQVVDPGP
VLRDMAFSKD HEQLYIMSER QLTRVPVESC GQYQSCGECL GSGDPHCGWC VLHNICTRKE
RCERSKEPRR FASEMKQCVR LTVHPNNISV SQYNVLLVLE TYNVPELSAG VNCTFEDLSE
MDGLVVGNQI QCYSPAAKEV PRIITENGDH HVVQLQLKSK ETGMTFASTS FVFYNCSVHN
SCLSCVESPY RCHWCKYRHV CTHDPKTCSF QEGRVKLPED CPQLLRVDKI LVPVEVIKPI
TLKAKNLPQP QSGQRGYECI LNIQGSEQRV PALRFNSSSV QCQNTSYSYE GMEINNLPVE
LTVVWNGHFN IDNPAQNKPG QCTLRQHCPA QESRWLELSG ANSKCTNPRI TEIIPVTGPR
EGGTKVTIRG ENLGLEFRDI ASHVKVAGVE CSPLVDGYIP AEQIVCEMGE AKPSQHAGFV
EICVAVCRPE FMARSSQLYY FMTLTLSDLK PSRGPMSGGT QVTITGTNLN AGSNVVVMFG
KQPCLFHRRS PSYIVCNTTS SDEVLEMKVS VQVDRAKIHQ DLVFQYVEDP TIVRIEPEWS
IVSGNTPIAV WGTHLDLIQN PQIRAKHGGK EHINICEVLN ATEMTCQAPA LALGPDHQSD
LTERPEEFGF ILDNVQSLLI LNKTNFTYYP NPVFEAFGPS GILELKPGTP IILKGKNLIP
PVAGGNVKLN YTVLVGEKPC TVTVSDVQLL CESPNLIGRH KVMARVGGME YSPGMVYIAP
DSPLSLPAIV SIAVAGGLLI IFIVAVLIAY KRKSRESDLT LKRLQMQMDN LESRVALECK
EAFAELQTDI HELTSDLDGA GIPFLDYRTY TMRVLFPGIE DHPVLRDLEV PGYRQERVEK
GLKLFAQLIN NKVFLLSFIR TLESQRSFSM RDRGNVASLI MTVLQSKLEY ATDVLKQLLA
DLIDKNLESK NHPKLLLRRT ESVAEKMLTN WFTFLLYKFL KECAGEPLFS LFCAIKQQME
KGPIDAITGE ARYSLSEDKL IRQQIDYKTL VLSCVSPDSA NSPEVPVKIL NCDTITQVKE
KILDAIFKNV PCSHRPKAAD MDLEWRQGSG ARMILQDEDI TTKIENDWKR LNTLAHYQVP
DGSVVALVSK QVTAYNTVNN STVSRTSASK YENMIRYTGS PDSLRSRTPM ITPDLESGVK
MWHLVKNHEH GDQKEGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF STAHRGSALP
LAIKYMFDFL DEQADKHGIH DPHVRHTWKS NCLPLRFWVN MIKNPQFVFD IHKNSITDAC
LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY AKDIPSYKNW VERYYSDIGK MPAISDQDMN
AYLAEQSRMH MNEFNTMSAL SEIFSYVGKY SEEILGPLDR DDQCGKQKLA YKLEQVITLM
SLDS
//
