ID G1RRD0_NOMLE Unreviewed; 826 AA.
AC G1RRD0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Leucine rich repeats and guanylate kinase domain containing {ECO:0000313|Ensembl:ENSNLEP00000015794.1};
GN Name=LRGUK {ECO:0000313|Ensembl:ENSNLEP00000015794.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000015794.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000015794.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000015794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; ADFV01196473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01196479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003261407.1; XM_003261359.3.
DR AlphaFoldDB; G1RRD0; -.
DR STRING; 61853.ENSNLEP00000015794; -.
DR Ensembl; ENSNLET00000016599.2; ENSNLEP00000015794.1; ENSNLEG00000012993.2.
DR GeneID; 100584466; -.
DR KEGG; nle:100584466; -.
DR CTD; 136332; -.
DR eggNOG; KOG0531; Eukaryota.
DR eggNOG; KOG0707; Eukaryota.
DR GeneTree; ENSGT00940000157992; -.
DR HOGENOM; CLU_019293_0_0_1; -.
DR InParanoid; G1RRD0; -.
DR OMA; EEDGCDY; -.
DR OrthoDB; 1331402at2759; -.
DR TreeFam; TF329158; -.
DR Proteomes; UP000001073; Chromosome 13.
DR CDD; cd00071; GMPK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23117; GUANYLATE KINASE-RELATED; 1.
DR PANTHER; PTHR23117:SF18; LEUCINE-RICH REPEAT AND GUANYLATE KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF12799; LRR_4; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00365; LRR_SD22; 7.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51450; LRR; 6.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 415..598
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 72..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..96
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..785
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 826 AA; 93376 MW; 28A9302DBBAE44D4 CRC64;
MATSERALLR TRAASLLRGL GRSRTGARSL QFRAEKERQR CWSSFPMGQK TKGRSNIASS
YLLQQLMHSY PELDADGDED QGEGEAVSEE SSESEMLNLE EEFDGVLREE AVAEALHHLG
RSGSGTEQVY LNLTLSGCNF IDVSILCGYV HLQKLDLSAN KIEDLSCVSC MPYLLELNVS
QNNLTTFFNF KPPKNLKKAD FSHNRISEIC DLSAYHALTT LILDGNEIEE ISGLEMCNNL
THLSLANNKI TTINGLNKLP IKILCLSNNQ IETITGLEDL KALQNLDLSH NQISSLQGLE
NHDLLEVINL EDNKIAELRE IEYIKNLPIL QVLNLLKNPI QEKSEYWFFV IFMLLRLTKL
DQKKIKVEEK VSAVNKYDPP PEVVAAQDHL THVVNSMIQP QRIFDSTLPS LDAPYPMLIL
AGPAACGKRE LAHCLCRQFS TYFRYGACHT TRPPYFGEGD RVDYHFISQE VFDEMVNMGK
FILTFSYGNH KYGLNRDTIE GIARDGLASC IHMEIEGVRS LKYSYFEPRY ILVVPMNKEK
YEGYLRRKGL FSRAEIEFAV SRVDLYIKIN QNFPGYFDAV INADDLDVAY QKLSQLIREY
LGLTEEPAKS LATTADAKTS HLKSEAHPTT YVSANMGDFL HSTDRNYLVK LWAKLSAKKT
PAERDSIHRQ HEAARQALMG RIRPDHTLLF QRGPVPAPLT SGLHYYTTLE ELQKSFDLCE
DYFKPPFGPY PEKSGKDSLV SMKCSLFRFC PWSKELPFQP PDGSISSCLG SEDSDSETGE
TLKALPIQSF SHEKESHQHR QHSVPVISRP GSNVKPTLPP IPQGRR
//
