ID G1RWR4_NOMLE Unreviewed; 595 AA.
AC G1RWR4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PAK4 {ECO:0000313|Ensembl:ENSNLEP00000017691.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017691.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000017691.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000017691.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; ADFV01060172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01060180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003270431.1; XM_003270383.3.
DR AlphaFoldDB; G1RWR4; -.
DR STRING; 61853.ENSNLEP00000017691; -.
DR Ensembl; ENSNLET00000018574.2; ENSNLEP00000017691.1; ENSNLEG00000014517.2.
DR GeneID; 100597455; -.
DR KEGG; nle:100597455; -.
DR CTD; 10298; -.
DR eggNOG; KOG0578; Eukaryota.
DR GeneTree; ENSGT00940000159792; -.
DR HOGENOM; CLU_000288_26_6_1; -.
DR InParanoid; G1RWR4; -.
DR OMA; QENGDPQ; -.
DR OrthoDB; 460351at2759; -.
DR TreeFam; TF105352; -.
DR Proteomes; UP000001073; Chromosome 17.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0071407; P:cellular response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0060996; P:dendritic spine development; IEA:Ensembl.
DR GO; GO:2000352; P:negative regulation of endothelial cell apoptotic process; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06657; STKc_PAK4; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR PANTHER; PTHR48015:SF17; SERINE_THREONINE-PROTEIN KINASE PAK 4; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 11..24
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 325..576
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 95..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..297
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 355
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 595 AA; 64506 MW; 200F4275488AEA3E CRC64;
MFGKRKKRVE ISAPSNFEHR VHTGFDQHEQ KFTGLPRQWQ SLIEESARRP KPLIDPACIT
SIQPGAPKTI VRGSKGAKDG ALTLLLDEFE NMSVTRSNSL RRDSPPPPAR VRQENGMPEE
PATTARGGPG KAGSRGRITG HSEAGGGSGD RRRAGPEKRP KSSREGSGGP QESSRDKRPL
SGPDVGTPQP AGLASGAKLA AGRPFNTYPR ADTDHPSRGA QGEPHDVAPN GPSAGSLAVP
QSSSSSSSRP PTRARGAPSP GVLGPHASEP QLAPPARTPA APAAPAVPGP PGPRSPQREP
QRVSHEQFRA ALQLVVDPGD PRSYLDNFIK IGEGSTGIVC IATVRSSGKL VAVKKMDLRK
QQRRELLFNE VVIMRDYQHE NVVEMYNSYL VGDELWVVME FLEGGALTDI VTHTRMNEEQ
IAAVCLAVLQ ALSVLHAQGV IHRDIKSDSI LLTHDGRVKL SDFGFCAQVS KEVPRRKSLV
GTPYWMAPEL ISRLPYGPEV DIWSLGIMVI EMVDGEPPYF NEPPLKAMKM IRDNLPPRLK
NLHKVSPSLK GFLDRLLVRD PAQRATAAEL LKHPFLAKAG PPASIVPLMR QNRTR
//
