ID G1RX28_NOMLE Unreviewed; 575 AA.
AC G1RX28;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Interleukin 1 receptor like 2 {ECO:0000313|Ensembl:ENSNLEP00000017805.1};
GN Name=IL1RL2 {ECO:0000313|Ensembl:ENSNLEP00000017805.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000017805.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000017805.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000017805.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; ADFV01084244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003274924.1; XM_003274876.2.
DR AlphaFoldDB; G1RX28; -.
DR STRING; 61853.ENSNLEP00000017805; -.
DR Ensembl; ENSNLET00000018693.3; ENSNLEP00000017805.1; ENSNLEG00000014624.3.
DR GeneID; 100587661; -.
DR CTD; 8808; -.
DR eggNOG; ENOG502QWEU; Eukaryota.
DR GeneTree; ENSGT01090000259985; -.
DR HOGENOM; CLU_025552_3_0_1; -.
DR InParanoid; G1RX28; -.
DR OMA; CHLNFPQ; -.
DR OrthoDB; 4322253at2759; -.
DR TreeFam; TF325519; -.
DR Proteomes; UP000001073; Chromosome 14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0004908; F:interleukin-1 receptor activity; IEA:InterPro.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0045582; P:positive regulation of T cell differentiation; IEA:Ensembl.
DR GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
DR CDD; cd05757; Ig2_IL1R-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR004074; IL-1_rcpt_I/II-typ.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF9; INTERLEUKIN-1 RECEPTOR-LIKE 2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01536; INTRLKN1R12F.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..575
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003421871"
FT TRANSMEM 336..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..111
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 126..197
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 381..536
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 575 AA; 65357 MW; 02386D9DEC96662C CRC64;
MWSLLLCGLS IALPLSVTAD GCKDIFTKNE MLSARQPFAF NCTFPPITSG EVSVTWYKNS
SKIPVSKIIQ SRIHQDETWI LFLPMEWGDS GVYQCVLKGR DSCHRIHVNL TVFEKHWCDT
SISGLPNLSD EYKQILHLGK DGSLTCHLHF PKSCVLGPIK WYKDCNEIKG ERFTVLQTRL
SVSNVSAEDR GNYACQAILT HSGKQYEVLN GITVSITERA GYGGSVPKII YPKNNSIEVQ
LGTTLIVDCN ITDTKDNTNL RCWRVNNTLV DDYYDESKRI REGVETHVSF REHNLYTVNI
TFLEVKMEDY GLPFMCHAGV STAYIILQLP APDFRAYLIG GLIALVAVAV SVVYIYNIFK
IDIVLWYRSA FHSTEAIEDG KLYDAYVLYP KPHKESQRHA VDALVLKILP KVLERQCGYK
LFIFGRDEFP GQAVANVIDE NVKLCRRLIV IVVPESLGFG LLKNLSEEQI AVYNALIQDG
MKVILIELEK IEDYTVMPES IQYIRQKHGA IRWHGDFTEQ SQCVKTKFWK TVRYHMPPRR
CRPSPPVQLP QHTPCYRTAG PKLGSRRKKC TLTTG
//
