ID G1RXP7_NOMLE Unreviewed; 1071 AA.
AC G1RXP7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Calcium voltage-gated channel auxiliary subunit alpha2delta 1 {ECO:0000313|Ensembl:ENSNLEP00000018024.2};
GN Name=CACNA2D1 {ECO:0000313|Ensembl:ENSNLEP00000018024.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000018024.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000018024.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000018024.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
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DR EMBL; ADFV01000476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000484; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01000485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1RXP7; -.
DR STRING; 61853.ENSNLEP00000018024; -.
DR Ensembl; ENSNLET00000018920.3; ENSNLEP00000018024.2; ENSNLEG00000014802.3.
DR eggNOG; KOG2353; Eukaryota.
DR GeneTree; ENSGT00940000155209; -.
DR HOGENOM; CLU_004660_0_0_1; -.
DR InParanoid; G1RXP7; -.
DR OMA; CLWPMLG; -.
DR TreeFam; TF315824; -.
DR Proteomes; UP000001073; Chromosome 11.
DR GO; GO:1990454; C:L-type voltage-gated calcium channel complex; IEA:Ensembl.
DR GO; GO:0098992; C:neuronal dense core vesicle; IEA:Ensembl.
DR GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0086057; F:voltage-gated calcium channel activity involved in bundle of His cell action potential; IEA:Ensembl.
DR GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR GO; GO:1904646; P:cellular response to amyloid-beta; IEA:Ensembl.
DR GO; GO:1902514; P:regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; IEA:Ensembl.
DR GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR GO; GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR CDD; cd18774; PDC2_HK_sensor; 1.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF6; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT DOMAIN 221..398
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1071 AA; 121308 MW; 7CAC6A513038C925 CRC64;
IKSWVDKMQE DLVTLAKTAS GVNQLVDIYE KYQDLYTVEP NNARQLVEIA ARDIEKLLSN
RSKALVRLAL EAEKVQAAHQ WREDFASNEV VYYNAKDDLD PEKNDSEPGS QRIKPVFIED
ANFGRQISYQ HAAVHIPTDI YEGSTIVLNE LNWTSALDEV FKKNREEDPS LLWQVFGSAT
GLARYYPASP WVDNSRTPNK IDLYDVRRRP WYIQGAASPK DMLILVDVSG SVSGLTLKLI
RTSVSEMLET LSDDDFVNVA SFNSNAQDVS CFQHLVQANV RNKKVLKDAV NNITAKGITD
YKKGFSFAFE QLLNYNVSRA NCNKIIMLFT DGGEERAQEI FTKYNKDKKV RVFTFSVGQH
NYDRGPIQWM ACENKGYYYE IPSIGAIRIN TQEYLDVLGR PMVLAGDKAK QVQWTNVYLD
ALELGLVITG TLPVFNITGQ FENKTNLKNQ LILGVMGVDV SLEDIKRLTP RFTLCPNGYY
FAIDPNGYVL LHPNLQPKPI GVGIPTINLR KRRPNIQNPK SQEPVTLDFL DAELENDIKV
EIRNKMIDGE SGEKTFRTLV KSQDERYIDK GNRTYTWTPV NGTDYSLALV LPTYSFYYIK
AKLEETITQA RYSETLKPDN FEESGYTFIA PRDYCNDLKI SDNNTEFLLN FNEFIDRKTP
NNPSCNADLI NRVLLDAGFT NELVQNYWSK QKNIKGVKAR FVVTDGGITR VYPKEAGENW
QENPETYEDS FYKRSLDNDN YVFTAPYFNK SGPGAYESGI MVSKAVEIYI QGKLLKPAVV
GIKIDVNSWI ENFTKTSIRD PCAGPVCDCK RNSDVMDCVI LDDGGFLLMA NHDDYTNQIG
RFFGEIDPSL MRHLVNISVY AFNKSYDYQS VCEPGAAPKQ GAGHRSAYVP SIADILQIGW
WATAAAWSIL QQFLLSLTFP RLLEAVEMED DDFTASLSKQ SCITEQTQYF FDNDSKSFSG
VLDCGNCSRI FHGEKLMNTN LIFIMVESKG TCPCDTRLLI QAEQTSDGPN PCDMVKQPRY
RKGPDVCFDN NVLEDYTDCG GVSGLNPSLW YIIGIQFLLL WLVSGSTHRL L
//
