ID G1S271_NOMLE Unreviewed; 612 AA.
AC G1S271;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Otopetrin 1 {ECO:0000313|Ensembl:ENSNLEP00000019609.1};
GN Name=OTOP1 {ECO:0000313|Ensembl:ENSNLEP00000019609.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000019609.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000019609.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000019609.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; ADFV01181319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01181324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003258533.1; XM_003258485.1.
DR AlphaFoldDB; G1S271; -.
DR STRING; 61853.ENSNLEP00000019609; -.
DR Ensembl; ENSNLET00000020599.2; ENSNLEP00000019609.1; ENSNLEG00000016176.2.
DR GeneID; 100599424; -.
DR KEGG; nle:100599424; -.
DR CTD; 133060; -.
DR eggNOG; KOG4740; Eukaryota.
DR GeneTree; ENSGT00940000159350; -.
DR HOGENOM; CLU_032913_1_0_1; -.
DR InParanoid; G1S271; -.
DR OMA; GNVCMRE; -.
DR OrthoDB; 3682573at2759; -.
DR TreeFam; TF313428; -.
DR Proteomes; UP000001073; Chromosome 20.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:Ensembl.
DR GO; GO:0032869; P:cellular response to insulin stimulus; IEA:Ensembl.
DR GO; GO:0009590; P:detection of gravity; IEA:Ensembl.
DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Ensembl.
DR GO; GO:0060336; P:negative regulation of type II interferon-mediated signaling pathway; IEA:Ensembl.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR PANTHER; PTHR21522:SF19; PROTON CHANNEL OTOP1; 1.
DR Pfam; PF03189; Otopetrin; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 65..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 132..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 576..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 67481 MW; 20CA673B3A08A233 CRC64;
MLEGLGLPAS PRGAAGASVA GSSGLAACPP PSPSAPRSPE SPAPRRGGVR ASVPQKLAEM
LSSQYGLIVF VAGLLLLLAW AVHAAGVSKS DLLCFLTALM LLQLLWMLWY VGRSSAHRRL
FRLKDTHAGA GWLRGSITLF AVITIILGCL KIGYFIGFSE CLSATEGVFP VTHSVHTLLQ
VYFLWGHAKD IIQSFKTLER FGVIHSVFTN LLLWANSVLN ESKHQLNEHK ERLITLGFGN
ITTVLDDHTP QCNCTPPTLC TAISHGIYYL YPFNIEYQIL ASTMLYVLWK NIGRKVDSHQ
HQKMQFKSDG VMMGAVLGLT ALAATIAVVV VYLIHIGRSK TKSESALIMF YLYAITLMML
MGAAALAGIR IYRIDEKSLD ESKNPARKLD SDLLVGTASG SWLISWGSIL AILCAEDHPH
YTWYNLPYSI LVIVEKYIQN LFIFESIHRE PEELSEDIQT LRVVTVCNGN TMPLASSCLK
SGGVAGDVAP RGKDMPPAAN VNVCMRESCD KEEEKQEENS WGGSPSPVHL PRFLQGNAKR
KVLRNIAAFL FLCNISLWIP PAFGCRPEYD NGLEEIVFGF EPWIIVVNLA MPFSIFYRMH
AAASLFEVYC KI
//
