ID G1S4E5_NOMLE Unreviewed; 712 AA.
AC G1S4E5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=ERCC excision repair 6 like 2 {ECO:0008006|Google:ProtNLM};
GN Name=ERCC6L2 {ECO:0000313|Ensembl:ENSNLEP00000020383.2};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000020383.2, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000020383.2, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000020383.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; ADFV01190463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; ADFV01190467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1S4E5; -.
DR STRING; 61853.ENSNLEP00000020383; -.
DR Ensembl; ENSNLET00000021399.2; ENSNLEP00000020383.2; ENSNLEG00000016784.2.
DR eggNOG; KOG0387; Eukaryota.
DR GeneTree; ENSGT00940000161328; -.
DR HOGENOM; CLU_000315_17_10_1; -.
DR InParanoid; G1S4E5; -.
DR OMA; DGVIWPY; -.
DR TreeFam; TF351516; -.
DR Proteomes; UP000001073; Chromosome 1a.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd18005; DEXHc_ERCC6L2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR CDD; cd20400; Tudor_ERCC6L2; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45629:SF7; DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED; 1.
DR PANTHER; PTHR45629; SNF2/RAD54 FAMILY MEMBER; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT DOMAIN 146..332
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 523..673
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 81196 MW; 64AF938198E2B4D1 CRC64;
VQPGSAPPPG RMDPSAPQPR AETAGKDIWH PGERCLAPFP DNGKLCEASI KSITADENGK
SFAVVLYSDF QERKIPLKQL QEVKFVKDCP RSLIFDDEDL EKPYFPNRKF PSSSVAFKLS
DDGDSIPYTI NRYLRDYQRE GARFLYGHYI HGRGCILGDD MGLGKTVQVI SFLAAVLHKK
GTREDIENNM PEFLLRSMKK EPPSSTAKKM FLIVAPLSVL YNWKDELDTW GYFRVTILHG
NRKDNELIRV KQRKCEIALT TYETLRLCLD ELNSLEWSAV IVDEAHRIKN PKARVTEVMK
ALKCSVRIGL TGTILQNNTK ELWCVMDWAV PGLLGSRTYF KKQFSDPVEQ GQRHTATKRE
LATGRKAMQR LAKKMSGWFL RRTKTLIKDQ LPKKEDRMVY CSLTDFQKAV YQTVLETEDV
TLILQSSEPC TCRSGRKRRN CCYKTNSHGE TVKTLYLSYL TVLQKVANHV ALLQAASTSK
QQETLIKRIC DQVFSRFPDF VQKSKDAAFE TLSDPKYSGK MKVLQQLLNH CRKNRDKVLL
FSFSTKLLDV LQQYCMASGL DYRRLDGSTK SEERLKIVKE FNSTQDVNIC LVSTMAGGLG
LNFVGANVVV LFDPTWNPAN DLQAIDRAYR IGQCRDVKVL RLISLGTVEE IMYLRQIYKQ
QLHCVVVGSE NAKRYFEAVQ GSKEHQGELF GIHNLFKFRS QGSCLTKDIL EV
//
