ID G1SBK8_NOMLE Unreviewed; 333 AA.
AC G1SBK8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=G protein-coupled receptor 174 {ECO:0000313|Ensembl:ENSNLEP00000022904.1};
GN Name=GPR174 {ECO:0000313|Ensembl:ENSNLEP00000022904.1};
OS Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC Nomascus.
OX NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000022904.1, ECO:0000313|Proteomes:UP000001073};
RN [1] {ECO:0000313|Ensembl:ENSNLEP00000022904.1, ECO:0000313|Proteomes:UP000001073}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Gibbon Genome Sequencing Consortium;
RL Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSNLEP00000022904.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; ADFV01047445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003269050.1; XM_003269002.2.
DR AlphaFoldDB; G1SBK8; -.
DR Ensembl; ENSNLET00000024072.2; ENSNLEP00000022904.1; ENSNLEG00000019047.2.
DR GeneID; 100590088; -.
DR KEGG; nle:100590088; -.
DR CTD; 84636; -.
DR eggNOG; ENOG502QSC0; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; G1SBK8; -.
DR OMA; YLFLMHP; -.
DR OrthoDB; 3076997at2759; -.
DR TreeFam; TF350009; -.
DR Proteomes; UP000001073; Chromosome X.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0045125; F:bioactive lipid receptor activity; IEA:Ensembl.
DR GO; GO:0043029; P:T cell homeostasis; IEA:Ensembl.
DR CDD; cd15152; 7tmA_GPR174-like; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR047836; GPR174_7tmA.
DR PANTHER; PTHR24232; G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24232:SF86; G-PROTEIN COUPLED RECEPTOR 174-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01157; P2YPURNOCPTR.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001073};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..292
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 333 AA; 38334 MW; A7DD4BAE9B18AAB7 CRC64;
MPANYTCTGP DGDNTDFRYF IYAVTYTIIL VPGLIGNILA LWVFYGYMKE TKRAVIFMIN
LAIADLLQVL SLPLRIFYYL NHDWPFGPGL CMFCFYLKYV NMYASIYFLV CISVRRFCFL
MYPFRFHDCK QKYDLYISIA GWLIICLACV LFPLLRTSDD TPGNRTKCFV DLPTRNVNLA
QSVVMMTIGE LVGFVTPLLI VLYCTWKTVL SLQDKYPMAQ DLGEKQKALK MILTCAGVFL
ICFAPYHFSF PLDFLVKSNE IKSCLARRVI LIFHSVALCL ASLNSCLDPV IYYFSTNEFR
RRLSRQDLHD SIQLHAKSFV SNHTASTMTT ELC
//
