ID G1SD73_RABIT Unreviewed; 254 AA.
AC G1SD73;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=palmitoyl-protein hydrolase {ECO:0000256|ARBA:ARBA00012423};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
GN Name=LYPLAL1 {ECO:0000313|Ensembl:ENSOCUP00000000342.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000342.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000000342.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000000342.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000000342.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000342.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. AB hydrolase 2
CC family. {ECO:0000256|ARBA:ARBA00006499}.
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DR EMBL; AAGW02025685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002717553.2; XM_002717507.3.
DR AlphaFoldDB; G1SD73; -.
DR SMR; G1SD73; -.
DR STRING; 9986.ENSOCUP00000000342; -.
DR PaxDb; 9986-ENSOCUP00000000342; -.
DR Ensembl; ENSOCUT00000000388.4; ENSOCUP00000000342.3; ENSOCUG00000000388.4.
DR GeneID; 100355314; -.
DR KEGG; ocu:100355314; -.
DR CTD; 127018; -.
DR eggNOG; KOG2112; Eukaryota.
DR GeneTree; ENSGT00940000159171; -.
DR HOGENOM; CLU_049413_3_6_1; -.
DR InParanoid; G1SD73; -.
DR OMA; LEYPHIK; -.
DR OrthoDB; 4670340at2759; -.
DR TreeFam; TF314619; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000000388; Expressed in kidney and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:Ensembl.
DR GO; GO:0160049; P:negative regulation of cGAS/STING signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR003140; PLipase/COase/thioEstase.
DR PANTHER; PTHR10655:SF71; LYSOPHOSPHOLIPASE-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR10655; LYSOPHOSPHOLIPASE-RELATED; 1.
DR Pfam; PF02230; Abhydrolase_2; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 30..242
FT /note="Phospholipase/carboxylesterase/thioesterase"
FT /evidence="ECO:0000259|Pfam:PF02230"
SQ SEQUENCE 254 AA; 27963 MW; 70A8044F460C32E3 CRC64;
MRAPSGCLRA CVFPTMAAAS GSVGLPRCLV SPAGRHSASL IFLHGSGDSG LGLRTWIKQV
LNQDLTFQHI KIIYPTAPSR PYTPLNGSIS NVWFDRFKIS NDCPEHIESI DIMCKVLSGL
IDEEVKSGIK KNRILIGGFS MGGCMAMHLA YRNHQDVAGV FALSSFLNKG SAVYEALKKS
HGVLPELFQC HGTADELVLH SWGEETNSLL KSLGVSTRFH SLPNVYHELN KTELEKLKSW
ILTKLPGEME RQNE
//
