ID G1SFR1_RABIT Unreviewed; 984 AA.
AC G1SFR1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Cysteine rich transmembrane BMP regulator 1 {ECO:0000313|Ensembl:ENSOCUP00000001371.3};
GN Name=CRIM1 {ECO:0000313|Ensembl:ENSOCUP00000001371.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001371.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001371.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001371.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001371.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001371.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02005935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005936; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005937; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005940; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02005942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SFR1; -.
DR SMR; G1SFR1; -.
DR STRING; 9986.ENSOCUP00000001371; -.
DR PaxDb; 9986-ENSOCUP00000001371; -.
DR Ensembl; ENSOCUT00000001596.3; ENSOCUP00000001371.3; ENSOCUG00000001595.4.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160910; -.
DR HOGENOM; CLU_008434_0_0_1; -.
DR InParanoid; G1SFR1; -.
DR TreeFam; TF106451; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000001595; Expressed in ovary and 16 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Ensembl.
DR Gene3D; 6.20.200.20; -; 6.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR045813; CRIM1_C.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 4.
DR Pfam; PF19442; CRIM1_C; 1.
DR Pfam; PF00093; VWC; 6.
DR SMART; SM00214; VWC; 6.
DR SMART; SM00215; VWC_out; 4.
DR SUPFAM; SSF57603; FnI-like domain; 5.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 3.
DR PROSITE; PS51252; ANTISTASIN; 4.
DR PROSITE; PS01208; VWFC_1; 3.
DR PROSITE; PS50184; VWFC_2; 6.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 888..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..344
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 354..410
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 422..451
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 460..485
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 492..517
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 520..545
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 559..616
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 630..688
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 704..762
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 770..827
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
SQ SEQUENCE 984 AA; 108293 MW; 86091E448C148BF6 CRC64;
MGPYTCMGDP VKLLSSAWSS PGSCCHTESE PVGGRALSRS CSLARSLSPS LSVGHYLVVD
SFTDENWDDD QLLGFEPCNE NLISGCNIIN GKCECDTIRT CNNPFEFPRK DMCLSALKRI
EEEKPDCSKA RCEVQFSPRC PEDSILIEGY APPGECCPLP SRCVCNPAGC LRKVCQPRYL
NILVSKASGK PGECCDLYEC KPVFSVDCST VECPSVQQAV CPLDSYETQV RLTADGCCTL
PTRCECLSGL CGFPVCEVGS TPRIVSRGDG TPGKCCDVFE CVNETKPACV FNNVEYHDGD
MFRMDNCRFC RCQGGVSICF TAQCGELNCE RYYVPEGECC PVCEDPVYPF NNPAGCYANG
QIRAHGDRWR EDDCTFCQCI NGEPHCVATA CGQSCMHPVK VPGECCPVCE EPTYITIDPP
ACGELSNCTL TEKDCIYGFK LDHNGCRTCQ CKNREELCAG LKRGCTLDCP FGFLTDAHNC
EICQCRPRPK KCRPIICDKY CPLGYLKNKH GCDICRCKKC PELPCSKICP LGFQQDSHGC
LICKCREVPA SAGPPVLSGT CLSMDGHHHK NEESWHDGCR ECYCHNGREM CALITCPVPA
CGNPTIHPGQ CCPSCADDFV VQKPELSTPS ICHAPGGEYF VEGETWNIDS CTQCTCHSGR
VLCETEVCPP LLCQNPSRTQ DSCCPQCTDE PLRPSSSHND SVPSYCKNDE GDIFLAAESW
KPDVCTSCVC MDSVISCYSE SCPSVSCERP VLRKGQCCPY CIEDTVPKKA VCHFSGKAYA
DEERWDIDSC THCYCLQGQT LCSTVSCPPL PCVEPINVEG SCCPMCPEMY VPEPTNIPIE
KTNHHGEIDL EVPMWPTAGE NDIIHLPRGK HQSTDILYSS EGSSLDSIAS VVVPIVTCLS
VLIAFLFINQ KKQWIPLLCW YRTPTKPSSL NNQLVSVDCK KGSRVQVDSS QRMLRIAEPD
ARFSGFYSMQ KQNHLQADNF YQTV
//
