ID G1SGF8_RABIT Unreviewed; 905 AA.
AC G1SGF8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Complement component C6 {ECO:0000256|ARBA:ARBA00018265};
GN Name=C6 {ECO:0000313|Ensembl:ENSOCUP00000001666.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000001666.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000001666.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000001666.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000001666.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000001666.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Constituent of the membrane attack complex (MAC) that plays a
CC key role in the innate and adaptive immune response by forming pores in
CC the plasma membrane of target cells. {ECO:0000256|ARBA:ARBA00002409}.
CC -!- SUBUNIT: Component of the membrane attack complex (MAC). MAC assembly
CC is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds
CC sequentially C6, C7, C8 and 12-14 copies of the pore-forming subunit
CC C9. {ECO:0000256|ARBA:ARBA00025836}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AAGW02030539; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SGF8; -.
DR CORUM; G1SGF8; -.
DR PaxDb; 9986-ENSOCUP00000001666; -.
DR Ensembl; ENSOCUT00000001933.4; ENSOCUP00000001666.4; ENSOCUG00000001929.4.
DR eggNOG; ENOG502QPIM; Eukaryota.
DR GeneTree; ENSGT00940000156814; -.
DR HOGENOM; CLU_014082_0_0_1; -.
DR TreeFam; TF330498; -.
DR Proteomes; UP000001811; Chromosome 11.
DR Bgee; ENSOCUG00000001929; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 3.30.60.30; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR048828; C6_KAZAL.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR003884; FacI_MAC.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF4; COMPLEMENT COMPONENT C6; 1.
DR Pfam; PF21288; C6_KAZAL; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR Pfam; PF00084; Sushi; 2.
DR Pfam; PF00090; TSP_1; 3.
DR PRINTS; PR00764; COMPLEMENTC9.
DR SMART; SM00032; CCP; 2.
DR SMART; SM00057; FIMAC; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50923; SUSHI; 2.
DR PROSITE; PS50092; TSP1; 3.
PE 3: Inferred from homology;
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|ARBA:ARBA00022659, ECO:0000256|PROSITE-
KW ProRule:PRU00302}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..905
FT /note="Complement component C6"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023879911"
FT DOMAIN 176..493
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT DOMAIN 613..672
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 673..734
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 756..810
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DISULFID 146..164
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 158..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 643..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 905 AA; 101457 MW; 5AFF6B0D408A0DE5 CRC64;
MAGHSVLYLI LLSTLVNKGQ TCFCDHYAWT QWSSCSKTCN SGTQSRQRQI VADQYYWENS
CDRLCTKQET RGCNWQTCPI NCLLGDYGPW SDCDPCVEKQ FKVRDLLRPS QFGGQPCTEP
LVTFQRCIPS KLCKIETADC KDDFRCDSGR CIPSKLECNG ENDCGDNSDE RDCGRTKKVC
PRQYNPIPSV QLMGNGFHFL AGEPRGEVLD NSFTGGICKT VKSSRASNPF RVPANLESVN
FEVKTEEDDL ETDFYKDLIS LEKNENQRSS SQAIQASYKK DSSFIRIHKV IKVLNFTMKA
KDLQLSDVFL KALNHLPLEY NSALYSRIFD EFGTHYFASG SLGGVYDLLY QFSSEELKNS
GLTEEEAKNC VSVETRKSYV FFTKKKVHHQ CTTNKLSEKY EGSFLKGAEK SISLVRGGRS
EYAAALAWEK GNSGPEQKVF SEWLESVKDN PTVVDFELAP IVDLVRNIPC AVTKRNNLRK
AFQEYAAKFD PCRCAPCPNN GRPILSGTEC LCVCQSGTYG ENCERRSPDY KSNAVDGNWG
CWSSWSTCDA TYKRSRTREC SNPAPLQGGK ACEGETRQEE DCTFSIMENN GQPCVSDDED
IKEVDLPETE TDFGCLPPRP PENGFIWNEK QLYSVGEEVE ISCLTGFRAV GYQYHRCLPD
RTWRQGDVEC QRTGCLKPVV QDNLMLTPFQ RLYEIGASIE LTCPSGFVVA GPSKYTCSED
SWTPPISNSL TCEKDILTKL KGHCQPGQKP SGSECICLSP EEDCSHYSED LCVFDTDSSH
YFTLSGCKFL AEKCLKNQQL HFLHSGPCQD GPQLAWSLER TKLSYNSTKK ESCGYDTCYD
WEKCSASTST CVCLLPPQCS KGGNQLYCAK IGSSTREKTL NICEMGAIKC ANRKVEILHP
GRCLA
//
