ID G1SHC6_RABIT Unreviewed; 757 AA.
AC G1SHC6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Semaphorin 3B {ECO:0000313|Ensembl:ENSOCUP00000002027.3};
GN Name=SEMA3B {ECO:0000313|Ensembl:ENSOCUP00000002027.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002027.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002027.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002027.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002027.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002027.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the semaphorin family.
CC {ECO:0000256|ARBA:ARBA00009492}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; AAGW02044111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SHC6; -.
DR SMR; G1SHC6; -.
DR STRING; 9986.ENSOCUP00000002027; -.
DR PaxDb; 9986-ENSOCUP00000002027; -.
DR Ensembl; ENSOCUT00000002348.4; ENSOCUP00000002027.3; ENSOCUG00000002344.4.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000157756; -.
DR HOGENOM; CLU_009051_5_1_1; -.
DR InParanoid; G1SHC6; -.
DR TreeFam; TF316102; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000002344; Expressed in upper lobe of left lung and 17 other cell types or tissues.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF37; SEMAPHORIN-3B; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..757
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023804911"
FT DOMAIN 30..518
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 578..651
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 710..757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 741..757
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 757 AA; 83679 MW; 0FE2F4AC045B9344 CRC64;
MGRAEAAAMI LGLALLWAEG LGGTTPSPPR LRLSFQELQT RHGLRTFRLE RTCCYEALLV
DEERGRLFVG AENHVASLSL DNISKRAKKV AWPAPVEWRE ECNWAGKDIG TECMNFVKLL
HAYNRTHLLA CGTGAFHPTC AFVDVGHRPE EPTLRLDLRR LEDGKGKSPY DPRHRAASVL
VGEELYSGVA ADLMGRDFTI FRSLGQRPSL RTEPHDSRWL NEPKFVKVFW IPESENPDDD
KIYFFFRELA VEAAPALGRL SVSRVGQICR NDVGGQRSLV NKWTTFLKAR LVCSVPGVEG
DTHFDQLRSL PAEDVFLLSS RERRTPLLYA AFSTSSGVFQ GSAVCVYSMD DVRRAFLGPF
AHKEGPTHQW VSYQGRVPYP RPGMCPSKTF GTFGSTKDFP DDVIQFARNH PLMYNSVLPV
GGRPLFLRVG AGYTFTQIAA DRVAAADGHY DVLFIGTDVG TVLKVISMPK GSRPNAEGLL
LEELHVFQDA AAVTSMQISS KRHQLYVASR SAVAQIALHR CAAHGRACAE CCLARDPYCA
WDGATCTRFQ PSAKRRFRRQ DVRNGDPSTL CSGDSSRPVL LERKVFGVEG GSALLECEPR
SLQARMEWTF QRAGEAAHTQ VQAEERADLT AQGLLLRGLR RGDSGVYLCA AVEQGFSQPL
RRVALHVLSV AQAERLARAE EVAPAAALPG PKLWYRDFLQ LVEPGGGGGA NSLRMCQPQP
QPAAHAPAQT ARRKGRNRRT HTSEARAERG PRSAAHW
//
