ID G1SI62_RABIT Unreviewed; 499 AA.
AC G1SI62;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=PWP1 homolog, endonuclein {ECO:0000313|Ensembl:ENSOCUP00000002361.2};
GN Name=PWP1 {ECO:0000313|Ensembl:ENSOCUP00000002361.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002361.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002361.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002361.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002361.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002361.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02060966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002711466.1; XM_002711420.3.
DR AlphaFoldDB; G1SI62; -.
DR STRING; 9986.ENSOCUP00000002361; -.
DR PaxDb; 9986-ENSOCUP00000002361; -.
DR Ensembl; ENSOCUT00000002725.4; ENSOCUP00000002361.2; ENSOCUG00000002724.4.
DR GeneID; 100346785; -.
DR KEGG; ocu:100346785; -.
DR CTD; 11137; -.
DR eggNOG; KOG0270; Eukaryota.
DR GeneTree; ENSGT00390000017324; -.
DR HOGENOM; CLU_023867_1_1_1; -.
DR InParanoid; G1SI62; -.
DR OMA; CFVPRGV; -.
DR OrthoDB; 149677at2759; -.
DR TreeFam; TF314868; -.
DR Proteomes; UP000001811; Chromosome 4.
DR Bgee; ENSOCUG00000002724; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:1990889; F:H4K20me3 modified histone binding; IEA:Ensembl.
DR GO; GO:0140713; F:histone chaperone activity; IEA:Ensembl.
DR GO; GO:0033140; P:negative regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR044285; PWP1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR14091; PERIODIC TRYPTOPHAN PROTEIN 1; 1.
DR PANTHER; PTHR14091:SF0; PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 250..292
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 293..335
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 379..413
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 38..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 55592 MW; 9DF421B07C3A0015 CRC64;
MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGASE EEEAGSPSDD
GVQSARTQAR PREPLEDGDP EDDRALDDDE LAEYDLDKYD EDDPDAETLG ESLLGLTVYG
SNDQDPYVTL KDTEQYERED FLIKPTDNLI VCGRAEQEQC NLEVHVYNQE EDSFYVHHDI
LLSAYPLSVE WLNFDPSPDD STGNYIAVGN MTPVIEVWDL DIVDSLEPVF TLGSKLSKKK
KKKGKKSSSA EGHTDAVLDL SWNKLIRNVM ASASADNTVI LWDMSVGKPA ASLAVHTDKV
QTLQFHPFEA QTLISGSYDK SVALYDCRSP DESNRMWRFS GQIERVTWNH FSPCHFLAST
DDGFVYNLDA RSDKPVFTLN AHNDEISGLD LSSQIKGCLV TASADKYVKI WDILGDRPSL
VHSRDMKMGV LFCSSCCPDL PFVYAFGGQK EGLRVWDIST VSSVNEAFGR RERLVLGSTR
SSSVSGPFGS RSSDTPMES
//
