ID G1SIH7_RABIT Unreviewed; 960 AA.
AC G1SIH7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN Name=RNF31 {ECO:0000313|Ensembl:ENSOCUP00000002487.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002487.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002487.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002487.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002487.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002487.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- SIMILARITY: Belongs to the RBR family. {ECO:0000256|ARBA:ARBA00008278}.
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DR EMBL; AAGW02024122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SIH7; -.
DR PaxDb; 9986-ENSOCUP00000002487; -.
DR Ensembl; ENSOCUT00000002864.3; ENSOCUP00000002487.3; ENSOCUG00000002861.3.
DR eggNOG; KOG1812; Eukaryota.
DR GeneTree; ENSGT00530000064112; -.
DR HOGENOM; CLU_014581_0_0_1; -.
DR TreeFam; TF350529; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000002861; Expressed in blood and 19 other cell types or tissues.
DR ExpressionAtlas; G1SIH7; baseline.
DR GO; GO:0071797; C:LUBAC complex; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR CDD; cd19815; Bbox1_HOIP; 1.
DR CDD; cd20337; BRcat_RBR_HOIP; 1.
DR CDD; cd16631; mRING-HC-C4C4_RBR_HOIP; 1.
DR CDD; cd10464; PUB_RNF31; 1.
DR CDD; cd20351; Rcat_RBR_HOIP; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 1.20.58.2190; -; 1.
DR Gene3D; 6.10.140.1100; -; 1.
DR Gene3D; 4.10.1060.10; Zinc finger, RanBP2-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047543; Bbox1_RNF31-like.
DR InterPro; IPR047540; BRcat_RBR_RNF31-like.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR036339; PUB-like_dom_sf.
DR InterPro; IPR018997; PUB_domain.
DR InterPro; IPR047542; Rcat_RBR_RNF31-like.
DR InterPro; IPR026254; RNF31-like.
DR InterPro; IPR041031; RNF31_C.
DR InterPro; IPR040641; RNF31_PUB.
DR InterPro; IPR047541; RNF31_RBR_mRING-HC-like.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR001876; Znf_RanBP2.
DR InterPro; IPR036443; Znf_RanBP2_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR16004:SF2; E3 UBIQUITIN-PROTEIN LIGASE RNF31; 1.
DR PANTHER; PTHR16004; RING FINGER PROTEIN 31-RELATED; 1.
DR Pfam; PF18091; E3_UbLigase_RBR; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF09409; PUB; 1.
DR Pfam; PF18486; PUB_1; 1.
DR SMART; SM00647; IBR; 2.
DR SMART; SM00547; ZnF_RBZ; 3.
DR SUPFAM; SSF143503; PUG domain-like; 1.
DR SUPFAM; SSF90209; Ran binding protein zinc finger-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS01358; ZF_RANBP2_1; 3.
DR PROSITE; PS50199; ZF_RANBP2_2; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00322}.
FT DOMAIN 289..321
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 342..371
FT /note="RanBP2-type"
FT /evidence="ECO:0000259|PROSITE:PS50199"
FT DOMAIN 583..817
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT REGION 430..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 107288 MW; 10638200BB45C471 CRC64;
MPGKEEERAF LAAREELASA LRRDSGQMFS LEQLRPLLAT SLPPAARYLQ LDAARLIRCN
AHGEPRNYLS TLSTALNILE KYGRNLLSPQ RPRYWRGVKF NNPVFRSTVD AVQGGRDVLR
LYGYTEEQPD GLSFPEEQEE PDENQVAAVT LEVLLLRTEL SLWLQNAHPR QQALEQLLKG
KAEDDMLQLS EFGPLLREIA PGPLTTPSAP GSTPCSCFLC GSAPGTLSCP ACKQVLCAAC
DRLFHGHPSR AHHLRQTTHL SPSLPASAAL LPQPNSLVAL RDSSPSLDPA NAHQPWHCAA
CTRLNEPWAM LCVACGWPRG CKESRLEIEG PQDTGGQEPE LTRGRWACQS CTFENEAAAV
LCAMCERPRL AQPPSLVVDS QDPGFSSQPL QQGDTLLSSA QTHVWYCIHC TFGNSGPGWV
CAMCNRTSSP GPEQHAPRPS ASSLEKGLPK PRPLQCLSAS LPNSCGDPEK QRQDKMREEG
LQLVVMIRVS MGPGRRWGSA GEGFLNTKCC SLEVIWLLNS CGTLTPRVMS LVRRLLAVYA
LPSWGRAELA LALLQETPRN YELGDVVEAV RQSQDRAFLR RLLAQECAVC GWALPRNRMQ
ALISCECTIC PDCFRQHFTI ALKEKHITDM VCPACGRPDL TDDTQLLSYF STLDIQLRES
LEPDAYALFH KKLTEGVLMR DPKFLWCAQC SFGFIYEREQ LEATCPQCHQ TFCVRCKRQW
EEQHRGRSCE DFQNWKRTND PEYQAQGLAM YLQENGIDCP KCKFSYALAR GGCMHFHCTQ
CRHQFCSGCY NAFYAKNKCP DPNCRVKKSL HGHHPRDCLF YLRDWTAVRL QKLLQDNNVM
FNTEPPAGAR AVPGGGCRVM EQKEVPNGLK DEACGKETPA GHAGLCQAHY KEYLVSLINA
HSLDPATLYE VEELETATER YLHVRPQPLA GEDPPGYHAR LLQKLTEEVP LGQSIPRRRK
//
