ID G1SIQ1_RABIT Unreviewed; 209 AA.
AC G1SIQ1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Cell death inducing DFFA like effector b {ECO:0000313|Ensembl:ENSOCUP00000002567.3};
GN Name=CIDEB {ECO:0000313|Ensembl:ENSOCUP00000002567.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002567.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002567.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002567.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002567.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002567.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02024119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SIQ1; -.
DR STRING; 9986.ENSOCUP00000002567; -.
DR PaxDb; 9986-ENSOCUP00000002567; -.
DR Ensembl; ENSOCUT00000002953.3; ENSOCUP00000002567.3; ENSOCUG00000002953.3.
DR eggNOG; ENOG502RUS7; Eukaryota.
DR GeneTree; ENSGT00390000018596; -.
DR HOGENOM; CLU_090011_0_0_1; -.
DR InParanoid; G1SIQ1; -.
DR TreeFam; TF334321; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000002953; Expressed in liver and 16 other cell types or tissues.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0120013; F:lipid transfer activity; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0070300; F:phosphatidic acid binding; IEA:Ensembl.
DR GO; GO:0090110; P:COPII-coated vesicle cargo loading; IEA:Ensembl.
DR GO; GO:0097194; P:execution phase of apoptosis; IEA:Ensembl.
DR GO; GO:0160077; P:lipid droplet fusion; IEA:Ensembl.
DR GO; GO:0019915; P:lipid storage; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0090207; P:regulation of triglyceride metabolic process; IEA:Ensembl.
DR GO; GO:0034379; P:very-low-density lipoprotein particle assembly; IEA:Ensembl.
DR Gene3D; 3.10.20.10; -; 1.
DR InterPro; IPR003508; CIDE-N_dom.
DR PANTHER; PTHR12306; CELL DEATH ACTIVATOR CIDE; 1.
DR PANTHER; PTHR12306:SF10; CELL DEATH ACTIVATOR CIDE-B; 1.
DR Pfam; PF02017; CIDE-N; 1.
DR SMART; SM00266; CAD; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR PROSITE; PS51135; CIDE_N; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|PROSITE-ProRule:PRU00447};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 27..103
FT /note="CIDE-N"
FT /evidence="ECO:0000259|PROSITE:PS51135"
SQ SEQUENCE 209 AA; 23580 MW; 69D44DB5FEF19FB9 CRC64;
MEYLSALKSV SNMSSEFGRR VWTSAPPPRP FRVCDHKRTI RKGLTAATRQ ELLDKALETL
LLRGEPTLVL EEDGTAVESE DFFQLLEDDT CLMVLDSGQS WSPSGVLSYG LGQEKPKHSK
DIARITFDVY KQNPRDLFGS LNVKATFYGL YTMSCDFQGL GPKKVLREFL RWTSALLQGL
GHLLLGISST LRHLVEGAEQ WQRQGRLRS
//
