ID G1SMX6_RABIT Unreviewed; 645 AA.
AC G1SMX6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Cartilage acidic protein 1 {ECO:0000313|Ensembl:ENSOCUP00000004306.3};
GN Name=CRTAC1 {ECO:0000313|Ensembl:ENSOCUP00000004306.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004306.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004306.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004306.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004306.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004306.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02060723; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060724; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060725; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008268532.1; XM_008270310.2.
DR AlphaFoldDB; G1SMX6; -.
DR PaxDb; 9986-ENSOCUP00000004306; -.
DR Ensembl; ENSOCUT00000004977.4; ENSOCUP00000004306.3; ENSOCUG00000004978.4.
DR GeneID; 100352703; -.
DR KEGG; ocu:100352703; -.
DR CTD; 55118; -.
DR eggNOG; ENOG502QQ5V; Eukaryota.
DR GeneTree; ENSGT00390000013726; -.
DR HOGENOM; CLU_027473_0_0_1; -.
DR OMA; SQLNYGM; -.
DR OrthoDB; 3014186at2759; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000004978; Expressed in brain and 15 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR027039; Crtac1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR011519; UnbV_ASPIC.
DR PANTHER; PTHR16026; CARTILAGE ACIDIC PROTEIN 1; 1.
DR PANTHER; PTHR16026:SF0; CARTILAGE ACIDIC PROTEIN 1; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF13517; FG-GAP_3; 1.
DR Pfam; PF07593; UnbV_ASPIC; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..645
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003421458"
FT DOMAIN 559..606
FT /note="EGF-like calcium-binding"
FT /evidence="ECO:0000259|SMART:SM00179"
SQ SEQUENCE 645 AA; 70597 MW; 1D8451F3638AD33F CRC64;
MVRGTDPAMF RMLLGLLLLW LLPPTKGSQR AEPMFTAVTN SVLPPDYDSN PTQLNYGVAV
TDVDHDGDFE IVVAGYNGPN LVLKYDRAQK RLVNIAVDER SSPYYALRDR QGNAIGVTAC
DIDGDGREEI YFLNTNNAFS GVATYTDKLF KFRNNRWEDI LSDEVNVARG VASLFAGRSV
ACVDRTGSGR YSIYIANYAY GNVGPDALIE MDPEASDLSR GILALRDVAA EAGVSKYTGG
RGVSVGPILS SSASDIFCDN ENGPNFLFHN QGNGTFVDAA ASAGVDDPHQ HGRGVALADF
NRDGKVDIVY GNWNGPHRLY LQMSVHGKVR FRDIASPKFS MPSPVRTVIA ADFDNDQELE
IFFNNIAYRS PSANRLFRVI RREHGDPLIE ELNPGDALEP EGRGTGGVVT DFDRDGMLDL
ILSHGESMAQ PLSVFRGNQG FSNNWLRVVP RTRFGAFARG AKVVLYTKKS GAHLRIIDGG
SGYLCEMEPV AHFGLGKDEA SSVEVTWPDG KMASRSVASE EMNSVLEILY PREEDRPQDP
APLECGQGFS QRENGHCMDT NECIQFPFVC PRDKPVCVNT YGSYRCRTNK KCSRGYEPNE
DGTACVAQVA FLGGYPSAAF SISEPLSRAS YLSLGLGLCL QFYAL
//
