ID G1SPD8_RABIT Unreviewed; 269 AA.
AC G1SPD8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=FRAT regulator of WNT signaling pathway 1 {ECO:0000313|Ensembl:ENSOCUP00000004903.3};
GN Name=FRAT1 {ECO:0000313|Ensembl:ENSOCUP00000004903.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004903.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004903.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004903.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004903.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004903.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GSK-3-binding protein family.
CC {ECO:0000256|ARBA:ARBA00010422}.
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DR EMBL; AAGW02060708; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02060709; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SPD8; -.
DR SMR; G1SPD8; -.
DR STRING; 9986.ENSOCUP00000004903; -.
DR Ensembl; ENSOCUT00000005654.3; ENSOCUP00000004903.3; ENSOCUG00000005650.3.
DR eggNOG; ENOG502T09T; Eukaryota.
DR GeneTree; ENSGT00390000007081; -.
DR HOGENOM; CLU_101225_1_0_1; -.
DR InParanoid; G1SPD8; -.
DR TreeFam; TF330804; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000005650; Expressed in blood and 19 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0140678; F:molecular function inhibitor activity; IEA:Ensembl.
DR GO; GO:1904886; P:beta-catenin destruction complex disassembly; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0046825; P:regulation of protein export from nucleus; IEA:Ensembl.
DR InterPro; IPR008014; GSK3-bd.
DR PANTHER; PTHR35154; GBP PROTEIN; 1.
DR PANTHER; PTHR35154:SF1; PROTO-ONCOGENE FRAT1; 1.
DR Pfam; PF05350; GSK-3_bind; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 158..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..228
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 28589 MW; C523F9B5030E09E5 CRC64;
MPCGREEEEE AGEEAEGEEE EEEEEEEEEG SFLLLEQSVT LGGSGEVDRL VAQIGETLQL
DAAQDSPASP CAPPGRHSSS PRGLRRGEGG QGLVPRRAAA APPIVGRGGV TAPPVLFAAP
SGTVPPCLGG LPPIVWSELQ GIPQPLSGPC RRGWLRGAAS SRRLQQRRGS QPETRTSDDD
PHRLLQQLVL SGNLIKEAVR RLHSRRLQLR PKLPPCQLPG PLSAPAQEPR SPRSPRAACS
DPGARHVTGT PGTHSLAQPL EMGSRGHLQ
//
