ID G1SPI2_RABIT Unreviewed; 287 AA.
AC G1SPI2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Tetratricopeptide repeat domain 1 {ECO:0000313|Ensembl:ENSOCUP00000004955.2};
GN Name=TTC1 {ECO:0000313|Ensembl:ENSOCUP00000004955.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004955.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004955.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004955.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004955.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004955.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02027206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002710394.1; XM_002710348.3.
DR AlphaFoldDB; G1SPI2; -.
DR SMR; G1SPI2; -.
DR STRING; 9986.ENSOCUP00000004955; -.
DR PaxDb; 9986-ENSOCUP00000004955; -.
DR Ensembl; ENSOCUT00000005721.4; ENSOCUP00000004955.2; ENSOCUG00000005724.4.
DR GeneID; 100355113; -.
DR KEGG; ocu:100355113; -.
DR CTD; 7265; -.
DR eggNOG; KOG4234; Eukaryota.
DR GeneTree; ENSGT00940000157213; -.
DR HOGENOM; CLU_058463_3_0_1; -.
DR InParanoid; G1SPI2; -.
DR OMA; YSINFNQ; -.
DR OrthoDB; 5478550at2759; -.
DR TreeFam; TF317515; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000005724; Expressed in blood and 16 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46014; TETRATRICOPEPTIDE REPEAT PROTEIN 1; 1.
DR PANTHER; PTHR46014:SF1; TETRATRICOPEPTIDE REPEAT PROTEIN 1; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 184..217
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 1..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..120
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 287 AA; 32895 MW; 4F51AFEE294BA65E CRC64;
MGEKSENGKI PADLFSGLKL TDPQEAECAS APVPDPQSKL LKGDEAHPQE DQTEEECFHD
CRASFEEGEP GMDKVENKPN DVNSSELDEE YLVELEKNMP EEEKQRRREE STRLKEEGNE
QFKKGDYIEA ESSYSQALQM CPSCFQKDRS ILFSNRAAAR MKQDKKDMAI SDCSKAIQLN
PSYIRAILRR AELYEKTDKL DEALEDYKSV LEKDPSVYQA REACMRLPKQ IEERNERLKE
EMLGKLKDLG NLVLRPFGLS TENFQIKQDS STGSYSINFV QNPNNNR
//
