ID G1SRB8_RABIT Unreviewed; 1313 AA.
AC G1SRB8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=AT-rich interaction domain 4B {ECO:0000313|Ensembl:ENSOCUP00000005708.3};
GN Name=ARID4B {ECO:0000313|Ensembl:ENSOCUP00000005708.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005708.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005708.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000005708.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005708.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005708.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02026299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026300; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026302; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002717370.1; XM_002717324.3.
DR RefSeq; XP_017203216.1; XM_017347727.1.
DR SMR; G1SRB8; -.
DR STRING; 9986.ENSOCUP00000005708; -.
DR PaxDb; 9986-ENSOCUP00000005708; -.
DR Ensembl; ENSOCUT00000006604.3; ENSOCUP00000005708.3; ENSOCUG00000006605.4.
DR GeneID; 100352525; -.
DR KEGG; ocu:100352525; -.
DR CTD; 51742; -.
DR eggNOG; KOG2744; Eukaryota.
DR eggNOG; KOG3001; Eukaryota.
DR GeneTree; ENSGT00940000158149; -.
DR HOGENOM; CLU_007419_0_0_1; -.
DR InParanoid; G1SRB8; -.
DR OrthoDB; 445024at2759; -.
DR TreeFam; TF106427; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000006605; Expressed in blood and 15 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd16883; ARID_ARID4B; 1.
DR CDD; cd20460; Tudor_ARID4B_rpt1; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 1.10.150.60; ARID DNA-binding domain; 1.
DR InterPro; IPR012603; ARID4A/B_PWWP.
DR InterPro; IPR028853; ARID4B_ARID/BRIGHT.
DR InterPro; IPR001606; ARID_dom.
DR InterPro; IPR036431; ARID_dom_sf.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR002999; Tudor.
DR InterPro; IPR025995; Tudor-knot.
DR InterPro; IPR047476; Tudor_ARID4B_rpt1.
DR PANTHER; PTHR13964:SF24; AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 4B; 1.
DR PANTHER; PTHR13964; RBP-RELATED; 1.
DR Pfam; PF01388; ARID; 1.
DR Pfam; PF08169; RBB1NT; 1.
DR Pfam; PF11717; Tudor-knot; 1.
DR SMART; SM01014; ARID; 1.
DR SMART; SM00501; BRIGHT; 1.
DR SMART; SM00333; TUDOR; 2.
DR SUPFAM; SSF46774; ARID-like; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51011; ARID; 1.
PE 4: Predicted;
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 306..398
FT /note="ARID"
FT /evidence="ECO:0000259|PROSITE:PS51011"
FT REGION 123..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..658
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 912..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1258..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..306
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..468
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..565
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 863..887
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1008
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1054
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1145..1192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1195..1211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1313 AA; 147763 MW; 06539715825B6804 CRC64;
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE VQDDHIKGPL
KVGAVVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT LRRSSLCLKG ERHFAESETL
DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP EEESSSSSSD EDEDDRKQVD ELLGKVVCVD
YISLDKKKTL WFPALVVCPD CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTAPK
PDAILKQAFD QALEFHKSKT IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL GGFDNIESGA
VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA NIEFQMALPE KVMNKPCKEC
ENVKEIKIKE ENETEVKEIK VEEERNIIPK EEKPNEEEIE RKENIKPSLG SKKNLLESIP
TQSDQEKEVN IKKSEENENL EDNDDTTRVA ESLSIKVEAE EEKAKSGDET NKEEDEDDEE
VEEEEEEEEE EEEDEDDDVN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
EVLYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD KDEKYSPKNC
KLRRLSKPPF QTNPSPEMVS KLDLTDAKNS DTAHIKSIEI TSILNGLQAS ESSAEDSEQE
DERSTEDIDN NGKEESKIDH LTHTRIELIS KEEQNSSSLL EENKVHTDLV ICKPASKSPE
RLRKDVEGLS EDTDYEEDDV TKKRKEVKKD TMDKSSKPQI KRGKRRFCNT EECLKTGSPS
KKEEKTKGKE SLCIENSSNS SSDEDEEEKS KAKMTPTKKY NGLEDKRKSL RTTGFYSGFS
EVAEKRIKLL NNSDERLQNS RAKDRKDVWS SIQGQWPKKT LKELFSDSDT EAAASPPHPA
PEEGATEELL QTVAEEESCS PNVESEKPPP VNVDSKPIEE KTAEVNDRKA EFPSSGSNSV
LNTPPTTPES PSSVTVTEAS QQQSSVTVSE PLAPNQEEAR SIKSETDSTI EVDSVAGELQ
DLQSEGNSSP AGFDASVSSS SSNQPEPEHP EKACTGQKRV KDSQGGGSSS KKQKRSHKTT
VVNNKKKGKG TNSSDSEELS AGESVTKTQP VKSVSTGMKS HSTKSPARTQ SPGKCGKNGD
KDPDLKEASN RLPKVYKWSF QMSDLENLTS AERITVLQEK LQEIRKHYLS LKSEVASIDR
RRKRLKKKER ESAATSSSSS SPSSSSITAA VMLTLAEPSM SSASQNGMSV ECR
//
