ID G1SWS0_RABIT Unreviewed; 450 AA.
AC G1SWS0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007948.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000007948.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000007948.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000007948.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007948.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AAGW02039726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002719423.1; XM_002719377.3.
DR AlphaFoldDB; G1SWS0; -.
DR SMR; G1SWS0; -.
DR PaxDb; 9986-ENSOCUP00000007948; -.
DR Ensembl; ENSOCUT00000009207.3; ENSOCUP00000007948.3; ENSOCUG00000009206.3.
DR GeneID; 100343422; -.
DR CTD; 8687; -.
DR eggNOG; ENOG502SIYJ; Eukaryota.
DR GeneTree; ENSGT00940000162088; -.
DR HOGENOM; CLU_012560_8_0_1; -.
DR InParanoid; G1SWS0; -.
DR OrthoDB; 4640531at2759; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000009206; Expressed in autopod skin and 3 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF110; KERATIN, TYPE I CUTICULAR HA8; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 103..414
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 107..141
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 209..240
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 358..399
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 450 AA; 50279 MW; BF95CFDF634A5740 CRC64;
MTSCTGSSYP AGSIRSLGAR CVPIACSEVG VQYGPEGDTA PMCLSATVAH SNRVRVGNTP
LGRPSLCLPQ SCRTACPLPG TCHIPGNVGI CGAYGEVTLN GHEKETMQFL NDRLANYLEK
VRQLERENAE LETTIRETSK CHETSVCPDY QSYFRTIEEL QQKILCTKAE NVRIVIQIDN
AKLAADDFRI KHESERSLRQ LVEADMCGMH KLMDDLSLAK ADLEAQQESL KEEQLSLKSN
HEQEVNTLRC QLGDKLRIEL DTEPTIDLSR VLEEMRCQYE AMVETNRKDV EQWFQAQSEG
ISLQAMSCSE ELQCCQSEIL ELRCKVNALE VEREAQHNLK DCLQNSLCEA EARFGTELAQ
MQILISNVEE QLSEIRADLE RQNQEYQVLL DVKARLESEI NTYRSLLESE DCKLPCNPCS
TPAHCSLRPS CAPSTCWAPS APAASTGSRF
//
