ID G1SYS3_RABIT Unreviewed; 1133 AA.
AC G1SYS3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Trafficking protein particle complex subunit 11 {ECO:0000256|ARBA:ARBA00021520};
GN Name=TRAPPC11 {ECO:0000313|Ensembl:ENSOCUP00000008778.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008778.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008778.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008778.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008778.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008778.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in endoplasmic reticulum to Golgi apparatus
CC trafficking at a very early stage. {ECO:0000256|ARBA:ARBA00001995}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC {ECO:0000256|ARBA:ARBA00004222}.
CC -!- SIMILARITY: Belongs to the TRAPPC11 family.
CC {ECO:0000256|ARBA:ARBA00007051}.
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DR EMBL; AAGW02011540; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02011541; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02011542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709537.1; XM_002709491.3.
DR AlphaFoldDB; G1SYS3; -.
DR SMR; G1SYS3; -.
DR STRING; 9986.ENSOCUP00000008778; -.
DR PaxDb; 9986-ENSOCUP00000008778; -.
DR Ensembl; ENSOCUT00000010185.4; ENSOCUP00000008778.3; ENSOCUG00000010179.4.
DR GeneID; 100341758; -.
DR KEGG; ocu:100341758; -.
DR CTD; 60684; -.
DR eggNOG; KOG4386; Eukaryota.
DR GeneTree; ENSGT00390000006550; -.
DR HOGENOM; CLU_003649_0_0_1; -.
DR InParanoid; G1SYS3; -.
DR OMA; CVEYYRD; -.
DR OrthoDB; 6533at2759; -.
DR TreeFam; TF314022; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000010179; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030008; C:TRAPP complex; IEA:Ensembl.
DR GO; GO:0045054; P:constitutive secretory pathway; IEA:Ensembl.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0007030; P:Golgi organization; IEA:Ensembl.
DR GO; GO:0061635; P:regulation of protein complex stability; IEA:Ensembl.
DR InterPro; IPR021773; TPC11.
DR InterPro; IPR025876; TRAPPC11_C.
DR PANTHER; PTHR14374; FOIE GRAS; 1.
DR PANTHER; PTHR14374:SF0; TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 11; 1.
DR Pfam; PF11817; Foie-gras_1; 1.
DR Pfam; PF12742; Gryzun-like; 1.
PE 3: Inferred from homology;
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 264..521
FT /note="Trafficking protein particle complex subunit 11"
FT /evidence="ECO:0000259|Pfam:PF11817"
FT DOMAIN 1037..1095
FT /note="Trafficking protein particle complex subunit 11 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12742"
SQ SEQUENCE 1133 AA; 128653 MW; 9783E178F28AB2AF CRC64;
MSPTQWDFPV ELCCRPMAFV TLTGLDVVYN AVHRAVWDAF CANRRADRVP ISFKVLPGDH
EYPKCRPKRT SYEWYIPKGI LKTGWMNKHL NLVPALVVVF YELDWDEPQW KEKQSECATR
VEIVRQSLQG RNTKVAVVLI QKKTPLPPGE DVVASERAAA LCNACELSGK SLFVLPHTDH
LVGYIIRLEN AFYEHAQTYY YTEIRRVKSH KEFLNKTTHQ LLFVRHQFKI AFFSELKQDT
QNALKNYRTA YNLIHELRAH ETNILEIKTM AGFINYKICR LCFQHNTPLD AIAQFRKHVD
LCKKKIGSAD LAFEHAAWMS KQFQAFGDLF DEAIKLGLTA IQTQNPGFYY QQAAYYAQER
KQLAKTLCNH EASVMYPNPD PLETQTGVLD FYGQRSWRQG ILSFDLSDPE KEKAGVLAIQ
LKERSVVHSE IIISLLSNAV AQFKKYKCPR MKSHLMVQMG EEYYYAKDYT KALKLLDYVM
CDYRSEGWWT LLTSILTTAL KCSYLMAQLK DYITYSLELL GRASTLKDDQ KSRIEKNLIN
VLMNESPDPE PDCDVLAVKT AQKLWADRVS LVGSNVFTIG VQDFVPFVQC KAKFHAPSFH
VDVPVQFDIY LKADCPHPIR FSKLCVSFNN QEYNQFCVIE EASKASEVLE NLTQGKMCLV
PGKTRKLLFK FVAKTEDVGK KIEITSVDLV LGNETGRCVV LNWQGGGGDA ASSQEALQAA
RSFRRRPKLP DREVPWDCIV IQASTMIISR VPNISVRLRH EPPALANEMY CLVVTVQSHE
KTQIRDVKLT AGLKPGQDAN LTQKTHMTLH GTELCDESYP ALLTDVAVGD LHPGEQLEKT
LYVRCGTVGS RMFLVYVSYL INTTVEEKEI VCKCHKDETV TIETVFPFDV AVKFVSTKFE
HLERVYADIP FLLMTDLLSA SPWALTIVSS ELQLAPAMTA VDQLESQLDK VVLQTGESAS
ECFCLRCPSV GHVEGGVATG HYIVSWKRTS AMENIPVIST VITLPHVIVE NIPLHVNADL
PSFGRVRESL PVKYHLQNKT NLVQDVEISV EPSDAFMFSG LKQIRLRILP GTEQEMLYNF
YPLMAGYQQL PSLNINLLRF PNFTNQLLRR FIPTSIFVKP QGRLVDDTSI AAA
//
