ID G1SZI7_RABIT Unreviewed; 612 AA.
AC G1SZI7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Carnitine O-octanoyltransferase {ECO:0000313|Ensembl:ENSOCUP00000009089.2};
GN Name=CROT {ECO:0000313|Ensembl:ENSOCUP00000009089.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009089.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009089.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000009089.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009089.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009089.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; AAGW02061962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002713883.1; XM_002713837.3.
DR RefSeq; XP_008260019.1; XM_008261797.2.
DR RefSeq; XP_008260020.1; XM_008261798.2.
DR AlphaFoldDB; G1SZI7; -.
DR PaxDb; 9986-ENSOCUP00000009089; -.
DR Ensembl; ENSOCUT00000010546.4; ENSOCUP00000009089.2; ENSOCUG00000010544.4.
DR GeneID; 100355549; -.
DR KEGG; ocu:100355549; -.
DR CTD; 54677; -.
DR eggNOG; KOG3718; Eukaryota.
DR GeneTree; ENSGT01060000248556; -.
DR HOGENOM; CLU_013513_5_3_1; -.
DR OMA; DVWAKDY; -.
DR OrthoDB; 1429709at2759; -.
DR TreeFam; TF313836; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001811; Chromosome 10.
DR Bgee; ENSOCUG00000010544; Expressed in adult mammalian kidney and 15 other cell types or tissues.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF67; PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 23..596
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 327
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 612 AA; 70598 MW; CE1E1BCCBC1F9E5D CRC64;
MENQLAKSTE ERTFQYQDSL PSLPVPPLEE SLKKYLESVK PFANEEEYKK TEEIVQKFQN
GIGAELHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFAGPSPHF EHYWPPKEGT
HLERGSIILW HNLNYWQLLR KEKVPVDKVG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF
RTESEGHSPS HLAVLCRGRV FVFDVIHEGS LITPPEFLRQ LTHIQEKCRR EPEGPGIAAL
TSEERTRWAK AREYLISLDP ENLTLLEKIQ SSLFVYSMED GRPHVTPEDY SQIISILFSG
DPTVRWGDKS YNLISFSNGV FGCNCDHAPY DAMVMVHIAH YVDEKILENE GRWKGSEKVR
DLPFPEELVF TVDEKILNDI SQAKAQYLKE ASNLQFAAYA FTSFGKKLTK KKKLHPDTFI
QLALQLAYYR LHGRPGCCYE TAMTRYFYHG RTETLRPCTT EAVRWCQFMQ DPSASLLERQ
QKMLEAFAKH NKMMKECSSG RGFDRHLLGL LLTAREEGLP TPELYTDPLF SRSGGGGNFV
LSTSLVGYLR IQGVVVPMVH NGYGFFYHIR DDRFVVACSA WKSCPETDAE KLVQLIFHAF
HDMMQLMNTA HL
//
