ID G1T063_RABIT Unreviewed; 596 AA.
AC G1T063;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Kelch-like protein 36 {ECO:0000256|ARBA:ARBA00019802};
GN Name=KLHL36 {ECO:0000313|Ensembl:ENSOCUP00000009360.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009360.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009360.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009360.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009360.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Probable substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex which mediates the ubiquitination and subsequent
CC proteasomal degradation of target proteins.
CC {ECO:0000256|ARBA:ARBA00003098}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; G1T063; -.
DR SMR; G1T063; -.
DR STRING; 9986.ENSOCUP00000009360; -.
DR PaxDb; 9986-ENSOCUP00000009360; -.
DR Ensembl; ENSOCUT00000010880.4; ENSOCUP00000009360.3; ENSOCUG00000010881.4.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000157543; -.
DR HOGENOM; CLU_004253_14_3_1; -.
DR InParanoid; G1T063; -.
DR TreeFam; TF328485; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000010881; Expressed in testis and 19 other cell types or tissues.
DR GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd18475; BACK_KLHL36; 1.
DR CDD; cd18266; BTB_POZ_KLHL36; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR45632:SF4; KELCH-LIKE PROTEIN 36; 1.
DR PANTHER; PTHR45632; LD33804P; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 3.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 36..103
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 596 AA; 67773 MW; 95A027390E16860B CRC64;
GSRVSQRRVP RVYRWAEHST TVLQRLNEQR LRGLFCDVVL VADEQRVPAH RNLLAVCSDY
FNSMFTIGMR EAFQKEVELI GASYIGLKAV VDFLYGGELA LDGGNIDYVL ETAHLLQIWT
VVDFCCEYLE QEVSEDNYLY LQELASIYSL KRLDAFIDGF ILSHFGTLSF TPDFLQNVSL
QKLCLYLSSS QVQRECEHDL LQAALQWLTQ QPEREGHAYQ VLEHIHFPLI PKNDLLHRVK
PAVCSLLPRE TNCEGFIEEA VRYHNSLAAQ PVMQTARTAL RTNEERLLFV GGEVSERCLE
LSDDTCYLDA KSEQWVKETP LPARRATTAC PCWGASFFIG DAASAFLYRY DPRCKQWIKV
ASMNQRRVDF YLASIADKLV AVGGRNENGA LSSVEMYSPR TDSWSYVAGL PRFTYGHAGT
IYKDFVYISG GHDYQIGPYR KNLLCYDHRT DVWEERRPMT TARGWHSMCC LGDTIYSIGG
SDDNIESMER FDVLGVEAYS PQCNQWTRVA PLLHANSESG VAVWQGRIYI LGGYSWENTA
FSKTVQVYDR EADKWSRGTD LPKAIAGVSA CVCALKPRLE DKKKKGKGKR LQERGQ
//
