ID G1T1H4_RABIT Unreviewed; 2647 AA.
AC G1T1H4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=Fibrillin 3 {ECO:0000313|Ensembl:ENSOCUP00000009923.4};
GN Name=FBN3 {ECO:0000313|Ensembl:ENSOCUP00000009923.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000009923.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000009923.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000009923.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000009923.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the LTBP family.
CC {ECO:0000256|ARBA:ARBA00038081}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- SIMILARITY: Belongs to the fibulin family.
CC {ECO:0000256|ARBA:ARBA00006127}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR SMR; G1T1H4; -.
DR STRING; 9986.ENSOCUP00000009923; -.
DR Ensembl; ENSOCUT00000011539.4; ENSOCUP00000009923.4; ENSOCUG00000011511.4.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; G1T1H4; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000011511; Expressed in embryo and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0001527; C:microfibril; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 26.
DR Gene3D; 2.10.25.10; Laminin; 42.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 7.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF46; LATENT-TRANSFORMING GROWTH FACTOR BETA-BINDING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 35.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF00683; TB; 7.
DR PIRSF; PIRSF036312; Fibrillin; 4.
DR SMART; SM00181; EGF; 43.
DR SMART; SM00179; EGF_CA; 39.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF57184; Growth factor receptor domain; 12.
DR SUPFAM; SSF57581; TB module/8-cys domain; 7.
DR PROSITE; PS00010; ASX_HYDROXYL; 35.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 21.
DR PROSITE; PS50026; EGF_3; 34.
DR PROSITE; PS01187; EGF_CA; 16.
DR PROSITE; PS51364; TB; 7.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor binding {ECO:0000256|ARBA:ARBA00023183};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..41
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 42..2647
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023908425"
FT DOMAIN 157..189
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 195..238
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 257..298
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 299..340
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 345..398
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 456..494
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 497..532
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 537..578
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 579..619
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 620..660
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 661..714
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 726..767
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 768..809
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 810..849
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 854..893
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 971..1012
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1013..1055
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1056..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1098..1139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1223..1260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1265..1303
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1306..1346
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1377..1417
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1456..1497
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1502..1553
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1571..1612
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1613..1654
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1697..1732
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1736..1778
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1779..1818
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1819..1856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1865..1918
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1934..1971
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1976..2015
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2057..2093
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2102..2143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2148..2201
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2213..2250
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2296..2334
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2335..2377
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2412..2449
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 161..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 179..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 501..511
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 814..824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1701..1711
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2647 AA; 279914 MW; 0E194270307703BB CRC64;
MTLQGPRRAG TGAGALPAAR SPLARLLLAW TVLSCVVGGR GRWDRAPGPA APGQVQRRSS
PGPLQGANVC GSRFHAYCCP GWRTLPGRSQ CVVPICRHPC GEGFCSQPNV CACADGTLAP
SCGVSRGSGC SVSCMNGASC QGESCLCPRG YTGTVCGQPV CDHGCHNRGR CIGPNHCSCV
YGFRGPQCER DYRTGPCFGQ VGAERCQQQL TGFPCTKALC CATVGRAWGL PCEPCPAQPH
PCRRGFIPNI HTGACQDVDE CRAVPGLCRG GSCLNTVGSF ECRCPAGHQL DDGGTTCEDL
DECSSRPGPC AGGDCANTVG SFVCLCPRGF TSSLDGSRCQ DRRVGTCFLM VIGGRCARDL
GGHSTHRQCC CDRGRCWAAG PAPELCPPRG SDEFQRLCVQ GLPLPPSHSG LPGFRLSAFG
PALGPARPRP QGSNGHVVPR LGPGSSSIGT VALNQTINIC RHFTNLCLHG RCLPTPSSYR
CECHVGYTQD VRGECIDVDE CTSGPCHHGD CVNTPGSYHC RCHEGFQATL TKQACLDVDE
CLISGGLCPL GRCVNTEGSF QCVCNAGFEL GPDGKSCVDH NECAASTVCL NGECVNEAGG
FTCVCKAGFL LAPSGRYCVD LDECQTPGIC VNGRCVNTEG SFRCQCPPGL EVGAGGRMCL
DTHMRSTCYG GSCTRPLPGA VTRSECCCSS PDHGFGQPCQ LCPAKDSAEF QALCTSGLGI
TADGRDIDEC ALDPEICTNG TCENLRGSYR CICNPGYQAG ATGQDCRDVD ECALNRLLCD
NGWCQNSPGS YSCSCPQGYG FQQDTETCED IDECLSSPCV NGACLNLAGS YTCECAPGSR
LGPSRTVCLD STRGTCWLKI EDGRCEANLQ GATLRSECCA TLGAAWGSPC EPCAMDPACA
RGFARVDGLT CEGNSLPAQG QVHVPGDAGA PPRSLWRRRQ KSPLPAVAGL CPPRPGTPQP
RSLHLTSPYP DVNECESFPG VCANGRCLNT VGSFRCECPQ GLTLDAAGRL CVDIDECRIS
PDLCGQGTCI NTLGSFQCEC FRGYASGPGM MKSCMDVDEC ARDPLLCRGG TCTNTDGSYT
CQCPPGHALT AEGTACEDVD ECSLSDGLCP HGQCINVIGT YQCSCHAGFQ ATPGRQGCVD
VDECLVRNGG CAVHCVNTEG GFQCSCGRGY VLTPDGRACA DVDECAENPS VCDLGQCINV
PGGHRCLCSD GFTTTRDRRA CVDVNECDLN PHICLHGSCE NTQGSFVCHC QLGYIVRKGA
AGCSDVDECE LGGHRCDSHA SCLNVPGTFS CRCQPGWVGD GFECHDQDEC VVQEHLCSPQ
ADCLNVLGSY RCTCRWGFVG DGFSCEGEIW EVEGRGPGEK ATEAECRWPV WHLLCTDVNE
CADPVNCING LCVNTPGSYF CICPQDFELN PSGVGCVDTR AGNCFLETFP RGDGGTSCSA
EIGVGVTRAS CSLPGDLDEC SAHTGVCGPG TCYNTLGSYT CVCPGDYLQI DGGSNCTDMR
KDVCFRSRDG TCRNELAFNV TRKMCCCSYN VGQAWNRPCE ACPTPATDYQ LLCGHPVPGF
VADVHTGRPL DVDECGEIPA ICAHGVCINQ IGSFRCECPV GFNYNSVLLA CEDVDECAGG
DSPCRRNANC FNSPGSYRCE CAPGYRLSPG GACEGRNECR EIPNVCSHGD CMDTEGSYVC
RCHRGFHTSA DRTLCLDVDE CDQQPCANGT CRNTVGSYNC FCFPGFVKTA SGDCVDVDEC
ATLVGQVCRS GECLNTPGSF LCLCRDGFWL TADGKNCVDT DECLSFAGTC LPGTCQNLEG
SFRCICPPGF QVQSDRCVDI DECSEEPSLC LFGTCTNSPG SFRCLCPPGF VLSDNGYRCF
DTRRSFCFTR FEAGKCSMPK PFNTTKTPCC CSKVPGEGWG DPCELCPQEG SVGFQELCPF
GHGAVPGLDD SREDVDECAE NPGICTNGAC VNTDGSFRCE CALGYSLDPA GISCGDIDEC
STGHPCGAGT CTNVVGGFLC ACADGFEPGP MMTCEDIDEC ALNPLLCAFR CHNTEGSYLC
TCPAGYALRE DGAMCRDVDE CADGSQDCHA RGMLCKNLMG TFTCVCPPGM RPQPSPGEGC
IDEDECHAQP GLCSHGHCVN TVGSFWCDCH EGFQPSPSLT ECHDVRQGAC FSEVLQAACQ
ARSSSGEAVS RATCCCGGGR AWGPRCELCP LPGTPAHRKL CPHGSGYTAE GRDVDECHVL
AHLCPHGECI NSIGSFHCHC QAGFAPDAAA TACLDVDECS QTPAPCSFLC KNTEGGFLCS
CPRGYLQQED GRTCADLDEC SSRKHNCKFL CVNTVGAFAC RCPPGFTQHR HTCFDDNECL
AHPSPCGARG RCHNAPGSFH CECYQGFTLD SSGHGCEGRA GHGVGSRLIG GGYRCDCPQG
FTLHSQWAQC VDENECVLSP ATCGTATCHN TLGGFRCVCP PGFDFDQALR GCQDVDECAG
PGSPCSYGCA NTAGSFLCGC PRGYLRAGQG HCVSGLGLGP GLQDAPDEKE EPLSPEACYE
CKINGLASGN RPRRSAHRDP QVSLATLDSE VPLTLHLNLS CLGQAERILE LRPAQRGPGG
QARYVIARGN EQGFFHIHHR GGLSSLRLGR RRPGPGTYQL EVVNVAGSWD ARPRVRALRL
KVQLQLL
//
