ID G1T2A7_RABIT Unreviewed; 221 AA.
AC G1T2A7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=glutathione transferase {ECO:0000256|ARBA:ARBA00012452};
DE EC=2.5.1.18 {ECO:0000256|ARBA:ARBA00012452};
GN Name=GSTA5 {ECO:0000313|Ensembl:ENSOCUP00000010273.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010273.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010273.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000010273.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010273.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010273.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC {ECO:0000256|ARBA:ARBA00011055}.
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DR EMBL; AAGW02018290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018291; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018292; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018293; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018296; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02018298; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002714434.1; XM_002714388.3.
DR AlphaFoldDB; G1T2A7; -.
DR Ensembl; ENSOCUT00000011946.3; ENSOCUP00000010273.3; ENSOCUG00000029486.2.
DR GeneID; 100353927; -.
DR KEGG; ocu:100353927; -.
DR eggNOG; KOG1695; Eukaryota.
DR GeneTree; ENSGT00940000163367; -.
DR HOGENOM; CLU_039475_4_0_1; -.
DR OrthoDB; 3412208at2759; -.
DR TreeFam; TF105321; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000029486; Expressed in liver and 15 other cell types or tissues.
DR ExpressionAtlas; G1T2A7; baseline.
DR GO; GO:0004364; F:glutathione transferase activity; IEA:UniProtKB-EC.
DR CDD; cd03208; GST_C_Alpha; 1.
DR CDD; cd03077; GST_N_Alpha; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR040079; Glutathione_S-Trfase.
DR InterPro; IPR004045; Glutathione_S-Trfase_N.
DR InterPro; IPR003080; GST_alpha.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR11571; GLUTATHIONE S-TRANSFERASE; 1.
DR PANTHER; PTHR11571:SF107; GLUTATHIONE S-TRANSFERASE A2; 1.
DR Pfam; PF14497; GST_C_3; 1.
DR Pfam; PF02798; GST_N; 1.
DR PRINTS; PR01266; GSTRNSFRASEA.
DR SFLD; SFLDG01205; AMPS.1; 1.
DR SFLD; SFLDS00019; Glutathione_Transferase_(cytos; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS50405; GST_CTER; 1.
DR PROSITE; PS50404; GST_NTER; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 3..83
FT /note="GST N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50404"
FT DOMAIN 85..208
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
SQ SEQUENCE 221 AA; 25419 MW; DE41621C32F8F119 CRC64;
MAGKPKLHYF NGRGRMESIR WLLAAAGVEF EEKFIETRED WDRIRKDGSL MYQQVPMVEI
DGMKLVQTRA IINYIANKHN LYGKDMKERA LIDMYVEGVA DLNEMTIVFP VHPPGVKETK
LSEIKDKAKN RYFPAFEKVL KSHGQDYLVG NKLSKADILL VELLYNVEEL DPSAIASFPQ
LQALKTRISN LPTVKKFLQP GSQRKPPTDE KTIEEAKKMF M
//
