ID G1T5E4_RABIT Unreviewed; 423 AA.
AC G1T5E4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Transcription factor IIIB 50 kDa subunit {ECO:0000256|ARBA:ARBA00039848};
DE AltName: Full=B-related factor 2 {ECO:0000256|ARBA:ARBA00042630};
GN Name=BRF2 {ECO:0000313|Ensembl:ENSOCUP00000011562.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011562.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011562.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011562.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011562.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_002720832.1; XM_002720786.3.
DR AlphaFoldDB; G1T5E4; -.
DR SMR; G1T5E4; -.
DR STRING; 9986.ENSOCUP00000011562; -.
DR PaxDb; 9986-ENSOCUP00000011562; -.
DR Ensembl; ENSOCUT00000013437.3; ENSOCUP00000011562.2; ENSOCUG00000013439.3.
DR GeneID; 100353971; -.
DR KEGG; ocu:100353971; -.
DR CTD; 55290; -.
DR eggNOG; KOG1598; Eukaryota.
DR GeneTree; ENSGT00390000002288; -.
DR InParanoid; G1T5E4; -.
DR OMA; DLPHPAY; -.
DR OrthoDB; 3059675at2759; -.
DR TreeFam; TF331596; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000013439; Expressed in frontal cortex and 16 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000126; C:transcription factor TFIIIB complex; IEA:Ensembl.
DR GO; GO:0001006; F:RNA polymerase III type 3 promoter sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0017025; F:TBP-class protein binding; IEA:InterPro.
DR GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR GO; GO:0006359; P:regulation of transcription by RNA polymerase III; IEA:Ensembl.
DR GO; GO:0070897; P:transcription preinitiation complex assembly; IEA:InterPro.
DR CDD; cd20555; CYCLIN_BRF2; 1.
DR Gene3D; 2.20.25.10; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 1.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR000812; TFIIB.
DR InterPro; IPR013150; TFIIB_cyclin.
DR InterPro; IPR013137; Znf_TFIIB.
DR PANTHER; PTHR11618:SF5; TRANSCRIPTION FACTOR IIIB 50 KDA SUBUNIT; 1.
DR PANTHER; PTHR11618; TRANSCRIPTION INITIATION FACTOR IIB-RELATED; 1.
DR Pfam; PF08271; TF_Zn_Ribbon; 1.
DR Pfam; PF00382; TFIIB; 1.
DR SUPFAM; SSF47954; Cyclin-like; 1.
DR SUPFAM; SSF57783; Zinc beta-ribbon; 1.
DR PROSITE; PS51134; ZF_TFIIB; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00469};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00469}.
FT DOMAIN 3..36
FT /note="TFIIB-type"
FT /evidence="ECO:0000259|PROSITE:PS51134"
FT REGION 316..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..376
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 423 AA; 46374 MW; D9E317A3369FB77B CRC64;
MPGGGRCPEC GSAELVEDSH YSQSQLVCSD CGCVVTEGTL TTTYSDEGHL REVTYSRSTG
ESEQASRSQQ RGLRRVRDLC RVLQLPPTFE DTAVAYYRQA YRHSGIRAAR LQKKEVLVGC
CVLITCRQHN WPLTMGTICT LLYADLDVFS STYLQMVKLL GLDVPSLCLA DLVKTYCSSF
KLFQASASVP AKYVEDKEKM LARTLQLVEL ANETWLVTGR HPLPVITAAT FLAWQSLRPS
GRLTCSLARF CKLASVDLPY PASSRLQELL AVLLRMAGQL AWLQVLKLDK RSVVKHIGDL
LQHRHTLVRA AFRDGAAEAE AREPGRQGPE QGQGEEAAAA AAAGSSSGLP QRKRPASPVP
LLPPCMLKPP KRIPPTPSVS TVTGDEDISD SEIEQYLRTP QEVREFQRAQ AASQAAGRVP
NPP
//
