ID G1T9G4_RABIT Unreviewed; 425 AA.
AC G1T9G4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Sorting nexin 4 {ECO:0000313|Ensembl:ENSOCUP00000013270.4};
GN Name=SNX4 {ECO:0000313|Ensembl:ENSOCUP00000013270.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013270.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013270.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013270.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013270.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013270.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; AAGW02013745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02013746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02013747; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02013748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02013749; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T9G4; -.
DR Ensembl; ENSOCUT00000015444.4; ENSOCUP00000013270.4; ENSOCUG00000015447.4.
DR eggNOG; KOG2273; Eukaryota.
DR GeneTree; ENSGT00930000151029; -.
DR HOGENOM; CLU_057138_0_0_1; -.
DR TreeFam; TF328543; -.
DR Proteomes; UP000001811; Chromosome 14.
DR Bgee; ENSOCUG00000015447; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd07622; BAR_SNX4; 1.
DR CDD; cd06864; PX_SNX4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR034902; PX_SNX4.
DR InterPro; IPR034783; SNX4.
DR InterPro; IPR037430; SNX4_BAR.
DR PANTHER; PTHR46596; SORTING NEXIN-4; 1.
DR PANTHER; PTHR46596:SF1; SORTING NEXIN-4; 1.
DR Pfam; PF00787; PX; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 19..145
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 425 AA; 49449 MW; B5878A0D193C8291 CRC64;
MDSYYMLKNN FLLKKIEISV SEAEKRTGRT AMNMQETYTA YLIETRSVEH ADGQSVLTDA
LWRRYSEFEL LRNYLLVYYP HVVVPPLPEK RAEFVWHKLS ADNMDPDFVE RRRIGLENFL
LRVASHPVLC RDKIFYLFLT QEGNWKETVN ETGFQLKADS RLKALNATFR VKNPDKRFTE
LKHYSDELQS VISHLLRVRA RVADRLYGVY KVHGNYGRVF SEWSAIEKEM GDGLQSAGHH
MDVYAASIDD ILEDEEHYAD QLKEYLFYAE ALRAVCRKHE LMQYDLEMAA QDLASKKQQC
EELATGTVRT FSLKGMTTKL FGQETPEQRE ARIKVLEEQI KEGEQQLKSK NLEGREFVKN
AWADIERFKE QKNRDLKEAL ISYAVMQISM CKKVGGWYLT LLPVCLDSCS CFSLLLGCIG
ICSHF
//
