ID G1TAD5_RABIT Unreviewed; 889 AA.
AC G1TAD5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 6 {ECO:0000313|Ensembl:ENSOCUP00000013623.3};
GN Name=KCNH6 {ECO:0000313|Ensembl:ENSOCUP00000013623.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013623.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013623.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013623.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013623.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013623.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AAGW02039960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TAD5; -.
DR SMR; G1TAD5; -.
DR STRING; 9986.ENSOCUP00000013623; -.
DR PaxDb; 9986-ENSOCUP00000013623; -.
DR Ensembl; ENSOCUT00000015859.3; ENSOCUP00000013623.3; ENSOCUG00000015857.3.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000157790; -.
DR HOGENOM; CLU_005746_2_4_1; -.
DR InParanoid; G1TAD5; -.
DR TreeFam; TF313130; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000015857; Expressed in upper lobe of left lung and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR10217:SF468; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 6; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 200..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..454
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 533..633
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 93..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 889 AA; 97999 MW; 7F1ECA85035F2C68 CRC64;
IPVPEGHQEP QCANWHGPST EHLLCSEHLV PSSQGAGHLL WASSFRCLVD VVPIKNEDGA
VIMFILNFED LAQLLAKSSN RSLSQRLLSH SFLGSHGSHS RPGGQGPGTG RGKYRTVSQI
PQFTLNFVEF NLEKHRSAST TEIEIIAPHK VVERTQNVTE KVTQVLSLGA DVLPEYKLQA
PRIHRGTILH YSPFKAVWDW LILLLVIYTA VFTPYSAAFL LSDQDESQRG ACGYTCSPLT
VVDLIVDIMF VVDIVINFRT TYVNTNDEVV SHPRRIAVHY FKGWFLIDMV AAIPFDLLIF
RTGSDETTTL IGLLKTARLL RLVRVARKLD RYSEYGAAVL FLLMCTFALI AHWLACIWYA
IGNVERPYLE PKIGWLDSLG AQLGKHYNGS DPASGPSVQD KYVTALYFTF SSLTSVGFGN
VSPNTNSEKV FSICVMLIGS LMYASIFGNV SAIIQRLYSG TARYHTQMLR VKEFIRFHQI
PNPLRQRLEE YFQHAWSYTN GIDMNAVLKG FPECLQADIC LHLHRALLQH CPAFHGASKG
CLRALAVKFK TTHAPPGDTL VHLGDVLSTL YFISRGSIEI LRDDVVVAIL GKNDIFGEPV
SLHARPGKSS ADVRALTYCD LHKIQRADLL EVLDMYPAFA DSFWSKLEVT FNLRDAEGGL
QSSPQQASGS RDHPGFFLSG NQSGAAPSLS ISDASGLWPE LLQPMPLKHR PPSPQGDPDC
WPRELGSRLD QLQAQMNRLE SRMSSDLSRV LQLLQQPVTQ GHTSCILGVP ASNDLALFPA
ASGTQSPGPR LSPAQAASFG DLDKCGPKHR NSSSRMPDLV VAADQTLTPL LDQTRPEGLL
SPLASPLHPL EAQGLVCGPR FPSLPEHLDS VPKQLEFQRH GSDPGFAGS
//
