ID G1TAY6_RABIT Unreviewed; 451 AA.
AC G1TAY6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Keratin, type I cytoskeletal 19 {ECO:0000256|ARBA:ARBA00040324};
DE AltName: Full=Cytokeratin-19 {ECO:0000256|ARBA:ARBA00041710};
DE AltName: Full=Keratin-19 {ECO:0000256|ARBA:ARBA00042489};
GN Name=KRT15 {ECO:0000313|Ensembl:ENSOCUP00000013859.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013859.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013859.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013859.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013859.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013859.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the organization of myofibers. Together with
CC KRT8, helps to link the contractile apparatus to dystrophin at the
CC costameres of striated muscle. {ECO:0000256|ARBA:ARBA00037562}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02039729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TAY6; -.
DR PaxDb; 9986-ENSOCUP00000013859; -.
DR Ensembl; ENSOCUT00000016126.4; ENSOCUP00000013859.3; ENSOCUG00000013123.4.
DR eggNOG; ENOG502QV0B; Eukaryota.
DR GeneTree; ENSGT00940000154403; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000013123; Expressed in skin of back and 15 other cell types or tissues.
DR ExpressionAtlas; G1TAY6; baseline.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF14; KERATIN, TYPE I CYTOSKELETAL 19; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 80..391
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 84..118
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 183..228
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 342..383
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 451 AA; 49224 MW; 973EE8F42C677FEA CRC64;
MTSYSYRQSS AASSFGGLGG GSVRFGAGGS FRAPSIHGGS GGRGVSVSSA RFVSSSSSGG
YGGGYGVALA GSDGLLAGNE KITMQNLNDR LASYLDKVRA LEQANGELEV KIRDWYQKQG
PGPSRDYSHY FKTIEDLRDK ILGATIENSK IVLQIDNARL AADDFRTKFE TEQALRLSVE
ADINGLRRVL DELTLARTDL ELQIEGLKEE LAYLKKNHEE EISALRGQVG GQVSVEVDSA
PGIDLGKILS EMRSQYEVMA EKNRKDAEAW FNSRTEELSR EVAVNTEQLK SSRSEVTDLR
RTMQGLEIEL QSQLSMKAAL EGTLAETEAR YGAQLAQIQA VISSIEAQLS DVRADTERQN
QEYQQLMDIK SRLEQEIATY RSLLEGQDAH YNNLPTSKIA TYRSLLEGQD AKMANVGIRE
VSLGSGGGGG GFRVHIEESV DGKVVSRKRE A
//
