ID G1TBK7_RABIT Unreviewed; 1742 AA.
AC G1TBK7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Pleckstrin homology domain interacting protein {ECO:0000313|Ensembl:ENSOCUP00000014110.4};
GN Name=PHIP {ECO:0000313|Ensembl:ENSOCUP00000014110.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014110.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014110.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014110.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014110.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014110.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02019049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02019056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1TBK7; -.
DR STRING; 9986.ENSOCUP00000014110; -.
DR PaxDb; 9986-ENSOCUP00000014110; -.
DR Ensembl; ENSOCUT00000016415.4; ENSOCUP00000014110.4; ENSOCUG00000016401.4.
DR eggNOG; KOG0644; Eukaryota.
DR GeneTree; ENSGT00950000183107; -.
DR HOGENOM; CLU_001108_0_0_1; -.
DR InParanoid; G1TBK7; -.
DR TreeFam; TF324197; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000016401; Expressed in blood and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR CDD; cd05529; Bromo_WDR9_I_like; 1.
DR CDD; cd05496; Bromo_WDR9_II; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR16266:SF4; PH-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR16266; WD REPEAT DOMAIN 9; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 116..157
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 158..199
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 200..235
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 298..332
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 399..441
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 1099..1169
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1256..1326
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 590..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1358..1428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1475..1525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1543..1567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1579..1598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1662..1694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 812..851
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1395..1428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1475..1496
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1497..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1742 AA; 197653 MW; A443EE8F3D270BC3 CRC64;
VKYYRHLAPD HLLQICHRLG PLLEQEIPQS VPGVQTLLGA GRQSLLRTNK SCKHVVWKGS
ALAALHCGRP PESPINYGSP PSIADTLFSR KLNGKYRLER LVPTAVYQHM KMHKRILGHL
SSVYCVTFDR TGRRIFTGSD DCLVKIWATD DGRLLATLRG HAAEISDMAV NYENTMIAAG
SCDKMIRVWC LRTCAPLAVL QGHSASITSL QFSPLCSGSK RYLSSTGADG TICFWLWDAG
TLKINPRPAK FTERPRPGVQ MICSSFSAGG MFLATGSTDH IIRVYFFGSG QPEKISELEF
HTDKVDSIQF SNTSNRFVSG SRDGTARIWQ FKRREWKSIL LDMATRPAGQ NLQGIEDKIT
KMKVTMVAWD RHDNTVITAV NNMTLKVWNS YTGQLIHVLM GHEDEVFVLE PHPFDPRVLF
SAGHDGNVIV WDLARGVKIR SYFNMIEGQG HGAVFDCKCS PDGQHFACTD SHGHLLIFGF
GSSSKYDKIA DQMFFHSDYR PLIRDANNFV LDEQTQQAPH LMPPPFLVDV DGNPHPSRYQ
RLVPGRENCR EEQLIPQMGV TSSGLNQVLS QQANQEISPL DSMIQRLQQE QDLRRSGEAG
INNNSRLSRG SLSSTSEVHS PPNIGLRRSG QIEGVRQMHS NAPRSEIATE RDLVAWSRRV
VVPELSAGVA SRQEEWRTAK GEEEIKTYRS EEKRKHLTVP KENKIPTISK NHAHEHFLDL
GESKKQQTNQ HNYRTRSALE ETPRPSEEVE NGTSSSDEGE VVAVSGGTSE EEERAWHSDG
SSSDYSSDYS DWTADAGINL QPPKKVPKHK TKKAETSSDE EEESEKQKQK QIKKERKKGN
EEKDGPVSPK KKKPKERKQK RLAVGELTEN GLTLEEWLPS TWITDTVYYF RQGHEAYVEM
ARKNKIYSIN PKKQPWHKME LREQELMKIV GIKYEVGLPT LCCLKLAFLD PDTGKLTGGS
FTMKYHDMPD VIDFLVLRQQ FDDAKYRRWN IGDRFRSVID DAWWFGTIES QEPLQPEYPD
SLFQCYNVCW DNGDTEKMSP WDMELIPNNA VFPEELGTSV PLTDNECRSL IYKPLDGEWG
TNPRDEECER IVTGINQLMT LDIASAFVAP VDLQAYPMYC TVVAYPTDLS TIKQRLENRF
YRRVSSLMWE VRYIEHNTRT FNEPGSPIVK SAKFVTDLLL HFIKDQTCYN MIPLYNSMKK
KVLSDSEEEE KDADVPGTST RKRKEHQPRR RLRNRAQSYD IQAWKKQCQE LLNLIFQCED
SEPFRQPVDL LEYPDYRDII DTPMDFATVR ETLEAGNYES PMELCKDVRL IFSNSKAYTP
SKRSRIYSMS LRLSAFFEEH ISSVLSDYKS ALRFHKRNTI TKRRKKRNRS SSVSSSAASS
PERKKRILKP HLKSEISTSA FSAPTRSIPP RHNAAQINGK TESSSVVRTR SNRVVVDPVI
TEQPSTSSAT KTFISKANTS AVPGKTILEN SVKHSKALNT TSSPGQSTFS HGTRNNSAKE
NIEKEKPVKR KMKSSVLSKT LSKSSAVIEQ GDCKNNAVIP GTIQVNGHGG QPSKLVKRGP
GRKPKVEINT NSGEVIHKKR GRKPKKLQYA KPENSEQNNV HPIRDEVVPS STCNFLSETN
IVKEDLLQKK SRGGRKPKRK MKTQKLDSDL IVPANVKVLR RSNRKKTDDP IDEEEEFEEL
KGSEPHMRTR NQGRRTAFYN EDDSEEEQRQ LLFEDTSLTF GTSSRGRVRK LTEKAKANLI
GW
//
